Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials

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#humans #diabetes-mellitus-type-1 #insulins #prospective-studies #vitamin-d

Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials

Dadon et al., 2024 | Nutrients | Systematic Review

Citation

Dadon Yuval, Hecht Sagie Lior, ... Mendlovic Joseph. Vitamin D and Insulin-Dependent Diabetes: A Systematic Review of Clinical Trials. Nutrients. 2024-Apr-03;16(7). doi:10.3390/nu16071042

Abstract

(1) Background: Vitamin D supplementation after type 1 diabetes mellitus (T1DM) onset has led to conflicting results on beta-cell preservation. Aim: This paper presents a systematic review to verify whether randomized prospective controlled trials (RCTs) demonstrate that improved vitamin D status confers protection on T1DM. (2) Methods: A systematic review was conducted up until 18 January 2024 according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching MEDLINE, MEDLINE In-Process, Embase, Cochrane Database of Systematic Reviews, and Cochrane Central Register of Controlled Trials, using keywords "vitamin D", "type 1 diabetes", and "children". (3) Results: Following the above-mentioned search process, 408 articles in PubMed and 791 in Embase met inclusion criteria. After removing duplicates, 471 articles remained. After exclusion criteria, 11 RCTs remained. Because of major heterogeneity in design and outcomes, no meta-analyses were conducted, allowing only for qualitative analyses. There was no strong evidence that vitamin D supplementation has lasting effects on beta-cell preservation or glycemic control in new-onset T1DM. (4) Conclusions: More rigorous, larger studies are needed to demonstrate whether vitamin D improves beta-cell preservation or glycemic control in new-onset T1DM. Because T1DM may cause osteopenia, it is advisable that patients with new onset T1DM have adequate vitamin D stores.

Key Findings

Following the above-mentioned search process, 408 articles in PubMed and 791 in Embase met inclusion criteria. After removing duplicates, 471 articles remained. After exclusion criteria, 11 RCTs remained. Because of major heterogeneity in design and outcomes, no meta-analyses were conducted, allowing only for qualitative analyses. There was no strong evidence that vitamin D supplementation has lasting effects on beta-cell preservation or glycemic control in new-onset T1DM. (4) Conclusions: More

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population new onset t1dm have
Sample Size 11
Age Range See abstract
Condition diabetes

MeSH Terms

  • Humans
  • Diabetes Mellitus, Type 1
  • Insulins
  • Prospective Studies
  • Vitamin D
  • Vitamins
  • Clinical Trials as Topic

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: vitamin-d-diabetes

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09