Sleep-related adverse events of smoking cessation drugs: A network meta-analysis of randomized controlled trials

source extracted confidence: high 2026-04-09
#humans #smoking-cessation #bupropion #varenicline #smoking

Sleep-related adverse events of smoking cessation drugs: A network meta-analysis of randomized controlled trials

Song et al., 2024 | Psychiatry Res | Narrative Review

Citation

Song Yubin, Park Yoon-A, ... Gwak Hye Sun. Sleep-related adverse events of smoking cessation drugs: A network meta-analysis of randomized controlled trials. Psychiatry Res. 2024-May;335:115874. doi:10.1016/j.psychres.2024.115874

Abstract

Smoking cessation medications have the potential to affect the functioning of the nervous system, leading to sleep disturbances. Our study aimed to compare the sleep-related side effects (such as insomnia, abnormal dreams, nightmares, and somnolence) induced by different smoking cessation medications in non-psychiatric smokers. We conducted a thorough search of five electronic databases (Cochrane, EMBASE, PubMed, PsycInfo, and Web of Science) for randomized controlled trials. This study was registered with the PROSPERO (registration number CRD42022347976). A total of 79 full-text articles, encompassing 36,731 participants, were included in our analysis. Individuals using bupropion, bupropion in combination with a nicotinic acetylcholine receptor agonist (NRA), and bupropion in conjunction with nicotine replacement therapy (NRT) exhibited a higher likelihood of experiencing insomnia compared to those using NRT alone. Bupropion plus NRA had the highest ranking on the surface under the cumulative ranking curve (SUCRA) for insomnia risk, while placebo had the lowest ranking. Additionally, NRA plus NRT ranked first for abnormal dream outcomes, NRA alone for nightmares, and nortriptyline for somnolence, based on the SUCRA results. Healthcare providers should exercise caution when prescribing smoking cessation drugs, particularly in consideration of their potential sleep-related side effects.

Key Findings

Healthcare providers should exercise caution when prescribing smoking cessation drugs, particularly in consideration of their potential sleep-related side effects.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 36731
Age Range See abstract
Condition insomnia

MeSH Terms

  • Humans
  • Smoking Cessation
  • Bupropion
  • Varenicline
  • Smoking
  • Sleep Initiation and Maintenance Disorders
  • Sleepiness
  • Tobacco Use Cessation Devices
  • Randomized Controlled Trials as Topic
  • Nicotinic Agonists
  • Sleep

Evidence Classification

  • Level: Narrative Review
  • Publication Types: Journal Article, Review, Network Meta-Analysis
  • Vertical: niacin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09