Efficacy of probiotic supplementation in the treatment of psoriasis-A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#psoriasis #probiotics #humans #treatment-outcome #severity-of-illness-index

Efficacy of probiotic supplementation in the treatment of psoriasis-A systematic review and meta-analysis

Wei et al., 2024 | J Cosmet Dermatol | Meta Analysis

Citation

Wei Kebo, Liao Xiaoshu, ... Wang Jun. Efficacy of probiotic supplementation in the treatment of psoriasis-A systematic review and meta-analysis. J Cosmet Dermatol. 2024-Jul;23(7):2361-2367. doi:10.1111/jocd.16299

Abstract

OBJECTIVE: Many studies have emphasized the possible role of probiotics in psoriasis, probiotic supplementation might be helpful to treat psoriasis. This study systematically evaluated the efficacy of probiotic supplementation for the treatment of psoriasis. METHODS: We searched some databases with keywords until November 10, 2023, including PubMed, Cochrane Library, Embase, and Web of Science. These keywords included probiotics, psoriasis RCT, and so on. After rigorous literature screening by two authors, five studies were identified. Eventually, the required data were independently extracted by another author. RESULTS: A total of five studies with 286 patients were included. The pooled results showed that the efficacy of probiotic supplementation was superior to placebo in the treatment of psoriasis. The Psoriasis Area and Severity Index (SMD = -1.40, 95% Cl = -2.63 to -0.17, p < 0.00001) and Dermatology Life Quality Index (SMD = -0.92, 95% Cl = -1.86 to 0.01, p < 0.00001). Score decreased after probiotic supplementation. CONCLUSIONS: The meta-analysis showed that probiotic supplementation could be a new treatment option for psoriasis.

Key Findings

A total of five studies with 286 patients were included. The pooled results showed that the efficacy of probiotic supplementation was superior to placebo in the treatment of psoriasis. The Psoriasis Area and Severity Index (SMD = -1.40, 95% Cl = -2.63 to -0.17, p < 0.00001) and Dermatology Life Quality Index (SMD = -0.92, 95% Cl = -1.86 to 0.01, p < 0.00001). Score decreased after probiotic supplementation.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 286
Age Range See abstract
Condition See abstract

MeSH Terms

  • Psoriasis
  • Probiotics
  • Humans
  • Treatment Outcome
  • Severity of Illness Index
  • Dietary Supplements
  • Quality of Life
  • Randomized Controlled Trials as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Systematic Review, Meta-Analysis
  • Vertical: probiotics

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09