Association between vitamin D receptor gene variants and neonatal sepsis: A systematic review and meta-analysis

Darnifayanti et al., 2024 | J Infect Public Health | Meta Analysis

Citation

Darnifayanti Darnifayanti, Rizki Diva Rayyan, ... Iqhrammullah Muhammad. Association between vitamin D receptor gene variants and neonatal sepsis: A systematic review and meta-analysis. J Infect Public Health. 2024-Mar;17(3):518-526. doi:10.1016/j.jiph.2024.01.011

Abstract

The objective of this systematic review and meta-analysis was elucidating the association of VDR SNPs (FokI, TaqI, BsmI, BgII, and ApaI) with neonatal sepsis. Literature search was performed to retrieve records published until August 2nd, 2023 (PROSPERO registration: CRD42023451355). Meta-analysis was carried out to determine the pooled estimates for Odds Ratio (OR). A total of four studies were included with 500 neonates (250 sepsis cases and 250 healthy controls). There was an association observed between TaqI SNP with neonatal sepsis for CT vs. CC+TT (OR=1.95) and TT vs CT+CC (OR=0.40). Moreover, the pooled estimates also suggested that CC vs. CT+TT (OR= 0.37) and C vs. T (OR=0.66) of FokI SNP were significantly associated with neonatal sepsis. SNP of BgII was found to be significantly associated with neonatal sepsis, but only reported in a single study.

Key Findings

SNP of BgII was found to be significantly associated with neonatal sepsis, but only reported in a single study.

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Infant, Newborn
• Humans
• Receptors, Calcitriol
• Neonatal Sepsis
• Polymorphism, Single Nucleotide
• Odds Ratio
• Case-Control Studies

Evidence Classification

• Level: Meta Analysis
• Publication Types: Meta-Analysis, Systematic Review, Journal Article
• Vertical: vitamin-d

Provenance

• PMID: 38306913
• DOI: 10.1016/j.jiph.2024.01.011
• PMCID: Not in PMC
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09