Treatment of ocular rosacea: a systematic review

source extracted confidence: high 2026-04-09
#humans #emulsions #rosacea #anti-bacterial-agents #cyclosporine

Treatment of ocular rosacea: a systematic review

Avraham et al., 2024 | J Dtsch Dermatol Ges | Systematic Review

Citation

Avraham Shani, Khaslavsky Sophie, ... Mukovozov Ilya. Treatment of ocular rosacea: a systematic review. J Dtsch Dermatol Ges. 2024-Feb;22(2):167-174. doi:10.1111/ddg.15290

Abstract

Rosacea is a common chronic skin disease distributed primarily around the central face. Ocular manifestations of rosacea are poorly studied, and estimates of prevalence vary widely, ranging from 6% to 72% in the rosacea population. Treatment options for ocular rosacea include lid hygiene, topical and oral antibiotics, cyclosporine ophthalmic emulsion, oral vitamin A derivatives, and intense pulsed light; however, a direct comparison of treatment methods for ocular rosacea is lacking. This review aims to compare treatment efficacy and adverse events for different treatment modalities in ocular rosacea. We performed a systematic review by searching Cochrane, MEDLINE and Embase. Title, abstract, full text screening, and data extraction were done in duplicate. Sixty-six articles met the inclusion criteria, representing a total of 1,275 patients. The most effective treatment modalities were topical antimicrobials and oral antibiotics, which achieved complete or partial response in 91% (n = 82/90) and 89% (n = 525/580) of patients respectively, followed by intense pulsed light (89%, n = 97/109 partial response), cyclosporine ophthalmic emulsion (87% n = 40/46), and lid hygiene (65%, n = 67/105). Combination treatments achieved a complete or partial response in 90% (n = 69/77). Results suggest that topical antimicrobials, oral antibiotics, intense pulsed light. and cyclosporine were the most efficacious single modality treatments.

Key Findings

and cyclosporine were the most efficacious single modality treatments.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 82
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Emulsions
  • Rosacea
  • Anti-Bacterial Agents
  • Cyclosporine
  • Skin Diseases

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: vitamin-a

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09