Serum level of vitamin D in patients with recurrent aphthous stomatitis: A systematic review and meta-analysis of case control studies

source extracted confidence: high 2026-04-09
#humans #stomatitis-aphthous #vitamin-d-deficiency #vitamin-d #case-control-studies

Serum level of vitamin D in patients with recurrent aphthous stomatitis: A systematic review and meta-analysis of case control studies

Safari-Faramani et al., 2024 | Clin Exp Dent Res | Meta Analysis

Citation

Safari-Faramani Roya, Salehi Mohsen, ... Omidpanah Neda. Serum level of vitamin D in patients with recurrent aphthous stomatitis: A systematic review and meta-analysis of case control studies. Clin Exp Dent Res. 2024-Feb;10(1):e794. doi:10.1002/cre2.794

Abstract

OBJECTIVES: Recurrent aphthous stomatitis (RAS) is an ulcerative condition with unknown etiology. The effect of vitamin D in the etiology of RAS is still a matter of controversy. In this study, we aimed at review the available evidence on the role of vitamin D deficiency in RAS etiology. MATERIAL AND METHODS: PubMed, Cochrane Library for Systematic Reviews, ISI Web of Science, Scopus, and EmBase were systematically searched for evidence on RAS and vitamin D up to January 2020. Retrieved records were screened and assessed by two of the authors independently. Newcastle-Ottawa scale was used to assess the quality of individual studies. AMSTAR tool was used for assessing the quality of the study. RESULTS: Eight studies including 383 healthy control and 352 patients with RAS were eligible for the meta-analysis. Serum vitamin D levels were significantly lower in RAS patients. The weighted mean difference was -7.90 (95% CI: -11.96 to -3.85). CONCLUSIONS: The results highlighted the importance of vitamin D deficiency in the etiology of RAS. However, more studies are needed to reach a robust decision. The observed association between vitamin D and RAS is probably due to the effect of vitamin D on the immune system.

Key Findings

Eight studies including 383 healthy control and 352 patients with RAS were eligible for the meta-analysis. Serum vitamin D levels were significantly lower in RAS patients. The weighted mean difference was -7.90 (95% CI: -11.96 to -3.85).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population ras were eligible for
Sample Size 352
Age Range See abstract
Condition deficiency

MeSH Terms

  • Humans
  • Stomatitis, Aphthous
  • Vitamin D Deficiency
  • Vitamin D
  • Case-Control Studies
  • Recurrence

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article, Research Support, Non-U.S. Gov't
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09