Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis

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#adult #humans #overweight #obesity #vitamin-d-deficiency

Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis

Huang et al., 2023 | BMC Public Health | Meta Analysis

Citation

Huang Xiao, Yang Yan, ... Zhang Jingjing. Association between vitamin D deficiency and lipid profiles in overweight and obese adults: a systematic review and meta-analysis. BMC Public Health. 2023-Aug-29;23(1):1653. doi:10.1186/s12889-023-16447-4

Abstract

OBJECTIVE: The association between vitamin D deficiency and lipid profiles in adults with overweight or obesity remains unclear and inconsistent. The aim of our study was to determine the relationship between lipid profiles and vitamin D deficiency in the overweight and obese adults. METHODS: Four databases, including PubMed, the Web of Science, EMBASE and the Cochrane Library, were used to identify all studies on vitamin D status and lipid levels, including the serum levels of triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL). The Weighted mean difference (WMD) with 95% confidence intervals (CIs) using random-effects models was used to assess the association between the lipid profile and vitamin D deficiency. RESULTS: Twenty-one articles that included a total of 7952 adults with overweight or obesity (BMI ≥ 25 kg/m2) were included. The overall results revealed that compared with the controls, individuals with vitamin D deficiency showed higher levels of TG (WMD = 15.01; 95%CI, 2.51-27.52) and TC (WMD = 8.61; 95%CI, 1.31-15.92). Moreover, vitamin D deficiency was related to an increased level of LDL (WMD = 6.12; 95%CI, 0.02-12.23). HDL level was inversely associated with the vitamin D deficiency status (WMD = -2.57; 95%CI, -4.26, -0.88). CONCLUSIONS: Among the adults with overweight or obesity, the vitamin D deficient group displayed impaired lipid profiles, including increased TG, TC and LDL levels and reduced HDL level.

Key Findings

Twenty-one articles that included a total of 7952 adults with overweight or obesity (BMI ≥ 25 kg/m2) were included. The overall results revealed that compared with the controls, individuals with vitamin D deficiency showed higher levels of TG (WMD = 15.01; 95%CI, 2.51-27.52) and TC (WMD = 8.61; 95%CI, 1.31-15.92). Moreover, vitamin D deficiency was related to an increased level of LDL (WMD = 6.12; 95%CI, 0.02-12.23). HDL level was inversely associated with the vitamin D deficiency status (WMD = 

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population vitamin d deficiency showed
Sample Size 7952
Age Range See abstract
Condition deficiency

MeSH Terms

  • Adult
  • Humans
  • Overweight
  • Obesity
  • Vitamin D Deficiency
  • Vitamin D
  • Cholesterol, HDL

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article, Research Support, Non-U.S. Gov't
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09