Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis

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#humans #vitamin-d #vitamins #psoriasis #vitamin-d-deficiency

Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis

Formisano et al., 2023 | Nutrients | Meta Analysis

Citation

Formisano Elena, Proietti Elisa, ... Pisciotta Livia. Psoriasis and Vitamin D: A Systematic Review and Meta-Analysis. Nutrients. 2023-Jul-30;15(15). doi:10.3390/nu15153387

Abstract

Psoriasis is a chronic immune-dysregulated inflammatory disease and hypovitaminosis D is considered a risk factor. We conducted an online database search to review and meta-analyze the relationship between vitamin D, other bone metabolism parameters, and psoriasis. The efficacy of oral vitamin D supplementation in improving Psoriasis Area and Severity Index (PASI) was also evaluated. Non-original articles, case reports, and animal studies were excluded. Bias risk was assessed according to the Cochrane Collaboration's tool and the Newcastle-Ottawa scale in randomized controlled trials (RCTs) and case-control studies, respectively. Unstandardized mean differences were used for data synthesis. Twenty-three studies reported serum 25 hydroxyvitamin D (25(OH)D) levels in 1876 psoriasis patients and 7532 controls. Psoriasis patients had significantly lower 25(OH)D levels than controls (21.0 ± 8.3 vs. 27.3 ± 9.8, p < 0.00001). Conversely, 450 psoriasis patients had lower levels of parathormone than 417 controls (38.7 ± 12.8 vs. 43.7 ± 16.5, p = 0.015). Four RCTs examined the effect of oral vitamin D supplementation on psoriasis for 173 patients and 160 patients were treated with placebo. No significant differences were found in PASI after 3, 6, and 12 months of supplementation. It is shown that 25(OH)D serum levels are significantly lower in psoriasis, but, although the granularity of RCT methodology may have influenced the pooled analysis, vitamin D supplementation did not seem to improve clinical manifestations.

Key Findings

It is shown that 25(OH)D serum levels are significantly lower in psoriasis, but, although the granularity of RCT methodology may have influenced the pooled analysis, vitamin D supplementation did not seem to improve clinical manifestations.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 173
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Vitamin D
  • Vitamins
  • Psoriasis
  • Vitamin D Deficiency
  • Calcifediol
  • Dietary Supplements

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09