Vitamin E and Multiple Health Outcomes: An Umbrella Review of Meta-Analyses

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#child #humans #vitamin-e #alpha-tocopherol #antioxidants

Vitamin E and Multiple Health Outcomes: An Umbrella Review of Meta-Analyses

Xiong et al., 2023 | Nutrients | Systematic Review

Citation

Xiong Zheyu, Liu Linhu, ... Wang Kunjie. Vitamin E and Multiple Health Outcomes: An Umbrella Review of Meta-Analyses. Nutrients. 2023-Jul-25;15(15). doi:10.3390/nu15153301

Abstract

The relationship between vitamin E intake or circulating α-tocopherol and various health outcomes is still debatable and uncertain. We conducted an umbrella review to identify the relationships between vitamin E intake or circulating tocopherol and health outcomes by merging and recalculating earlier meta-analyses. The connections that were found to be statistically significant were then classified into different evidence levels based on p values, between-study heterogeneity, prediction intervals, and small study effects. We finally included 32 eligible meta-analyses with four vitamin E sources and 64 unique health outcomes. Only the association between circulating α-tocopherol and wheeze or asthma in children was substantiated by consistent evidence. Suggestive evidence was suggested for seven results on endothelial function (supplemental vitamin E): serum C-reactive protein (CRP) concentrations (supplemental vitamin E), cervical cancer (dietary vitamin E), esophageal cancer (dietary vitamin E), cervical intraepithelial neoplasia (CIN, dietary vitamin E), pancreatic cancer (total vitamin E intake), and colorectal cancer (circulating α-tocopherol levels); all of these showed a protective effect consistent with the vitamin E source. In conclusion, our work has indicated that vitamin E is protective for several particular health outcomes. Further prospective studies are required when other factors that may contribute to bias are considered.

Key Findings

Further prospective studies are required when other factors that may contribute to bias are considered.

Outcomes Measured

  • C-reactive protein

Population

Field Value
Population See abstract
Sample Size 32
Age Range See abstract
Condition See abstract

MeSH Terms

  • Child
  • Humans
  • Vitamin E
  • alpha-Tocopherol
  • Antioxidants
  • Tocopherols
  • Diet

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09