B Vitamins as Adjunctive Treatment for Chronic Heart Failure

source extracted confidence: high 2026-04-09
#humans #vitamin-b-complex #pyridoxine #stroke-volume #ventricular-function-left

B Vitamins as Adjunctive Treatment for Chronic Heart Failure

Dkhillon et al., 2023 | Cardiovasc Hematol Disord Drug Targets | Other

Citation

Dkhillon Dzhastyn, Samogulova Alina, Kolobov Boris. B Vitamins as Adjunctive Treatment for Chronic Heart Failure. Cardiovasc Hematol Disord Drug Targets. 2023;23(1):64-71. doi:10.2174/1871529X23666230719090419

Abstract

INTRODUCTION: Vitamin B deficiency causes cardiac hypertrophy, reduced cardiac contractility, and arrhythmias.The purpose of this study is to perform a network meta-analysis of randomized controlled trials of vitamin B supplements in a group of 150 patients who meet the eligibility criteria.The study also aims to describe the effect of synthetic multivitamins (pyridoxine, folic acid, and cyanocobalamin) on the laboratory findings reflecting the severity of chronic heart failure (cholesterol, glucose, and fibrinogen). METHODS: The experiment involved a group of people (150 individuals) diagnosed with chronic heart failure with reduced left ventricular ejection fraction. The study compared serum levels of B vitamins measured after the therapy and at baseline. The second part of the study focused on the assessment of the laboratory findings reflecting the severity of cardiovascular pathology and indicating an increased risk of vascular catastrophes. RESULTS: Clinical trials among patients diagnosed with chronic heart failure showed that the intake of synthetic forms of pyridoxine, folic acid, and cyanocobalamin slightly increases systolic, diastolic and central venous pressure while decreasing the heart rate and increasing LVEF. Thiamine acts as a vasodilator. It reduces the cardiac afterload and improves heart function. CONCLUSION: The results obtained can be useful in terms of improving the comprehensive treatment strategy for chronic heart failure and further investigation of the effects produced by the intake of B vitamins.

Key Findings

Clinical trials among patients diagnosed with chronic heart failure showed that the intake of synthetic forms of pyridoxine, folic acid, and cyanocobalamin slightly increases systolic, diastolic and central venous pressure while decreasing the heart rate and increasing LVEF. Thiamine acts as a vasodilator. It reduces the cardiac afterload and improves heart function.

Outcomes Measured

  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population See abstract
Sample Size 150
Age Range See abstract
Condition deficiency

MeSH Terms

  • Humans
  • Vitamin B Complex
  • Pyridoxine
  • Stroke Volume
  • Ventricular Function, Left
  • Folic Acid
  • Vitamin B 12
  • Heart Failure
  • Chronic Disease

Evidence Classification

  • Level: Other
  • Publication Types: Journal Article, Network Meta-Analysis
  • Vertical: vitamin-b6

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09