Role of nutritional adjuncts in the management of gliomas: A systematic review of literature

source extracted confidence: high 2026-04-09
#humans #neoplasm-recurrence-local #glioma #progression-free-survival #brain-neoplasms

Role of nutritional adjuncts in the management of gliomas: A systematic review of literature

Pahwa et al., 2023 | Clin Neurol Neurosurg | Systematic Review

Citation

Pahwa Bhavya, Leskinen Sandra, ... D'Amico Randy S. Role of nutritional adjuncts in the management of gliomas: A systematic review of literature. Clin Neurol Neurosurg. 2023-Aug;231:107853. doi:10.1016/j.clineuro.2023.107853

Abstract

BACKGROUND: A variety of dietary adjuncts are known to affect the pathophysiology of glioma, making them a potential therapeutic adjunct to standard of care. We systematically reviewed clinical outcomes in glioma patients treated with one or more nutritional adjunct and/or an antimetabolite drug. METHODOLOGY: A systematic review of the literature following PRISMA guidelines was performed using Pubmed from inception till February 2023. In total, 22 manuscripts on nutrition representing 828 patients were included in the review. Statistical analyses were performed to compare the outcomes of various adjuncts. RESULTS: The median overall survival (OS) increased for newly diagnosed (21 months) and recurrent cases (10 months) when compared to historical data. For newly diagnosed cases, a ketogenic diet had the highest median OS of all the adjuncts (42.6 months) while in recurrent cases, a low copper diet coupled with 1 g penicillamine had the highest median OS (18.5 months). However, no statistically significant difference was observed in OS or progression-free survival (PFS) of newly diagnosed or recurrent gliomas. CONCLUSION: While nutritional adjuncts may offer a therapeutic benefit in the treatment of glioma, more human subject research is needed to derive meaningful conclusions.

Key Findings

The median overall survival (OS) increased for newly diagnosed (21 months) and recurrent cases (10 months) when compared to historical data. For newly diagnosed cases, a ketogenic diet had the highest median OS of all the adjuncts (42.6 months) while in recurrent cases, a low copper diet coupled with 1 g penicillamine had the highest median OS (18.5 months). However, no statistically significant difference was observed in OS or progression-free survival (PFS) of newly diagnosed or recurrent glio

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 828
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Neoplasm Recurrence, Local
  • Glioma
  • Progression-Free Survival
  • Brain Neoplasms

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09