Effect of probiotic yogurt on gestational diabetes mellitus: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#pregnancy #female #humans #diabetes-gestational #blood-glucose

Effect of probiotic yogurt on gestational diabetes mellitus: A systematic review and meta-analysis

Tabatabaeizadeh et al., 2023 | Diabetes Metab Syndr | Meta Analysis

Citation

Tabatabaeizadeh Seyed-Amir, Tafazoli Niayesh. Effect of probiotic yogurt on gestational diabetes mellitus: A systematic review and meta-analysis. Diabetes Metab Syndr. 2023-Apr;17(4):102758. doi:10.1016/j.dsx.2023.102758

Abstract

BACKGROUND AND AIMS: Gestational diabetes mellitus is one of the important complications of pregnancy and is related to many adverse events. There is evidence that probiotics can be considered a preventive and therapeutic option in gestational diabetes mellitus. In this meta-analysis, we have focused on the effect of probiotic yogurt as a natural product on gestational diabetes mellitus. METHODS: A systematic literature search was done through PUBMED/Medline, Google Scholar, Cochrane Library, and EBSCO up to December 2022. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines for the evaluation of the effect of probiotic yogurt on gestational diabetes mellitus. RESULTS: Four manuscripts with a total of 533 participants were included in this meta-analysis. There was a statistically significant association between probiotic yogurt and reduced risk of gestational diabetes mellitus (Pooled OR 0.35; 95% CI 0.19-0.62; I2 = 0.0%). Furthermore, the mean reduction in the fasting plasma glucose was significantly higher in the probiotic yogurt groups (Hedges' g = -0.37; 95% CI -0.68 to -0.05; I2 = 0.0%). CONCLUSION: This meta-analysis suggests that probiotic yogurt lowers the risk of gestational diabetes mellitus. Also, it is related to a significant reduction in fasting plasma glucose. These findings promise that probiotic yogurt could be regarded as a safe and low-cost therapy and preventive option for gestational diabetes mellitus. However, more randomized controlled trials with different doses and more probiotic strains with varying systems of delivery are warranted.

Key Findings

Four manuscripts with a total of 533 participants were included in this meta-analysis. There was a statistically significant association between probiotic yogurt and reduced risk of gestational diabetes mellitus (Pooled OR 0.35; 95% CI 0.19-0.62; I2 = 0.0%). Furthermore, the mean reduction in the fasting plasma glucose was significantly higher in the probiotic yogurt groups (Hedges' g = -0.37; 95% CI -0.68 to -0.05; I2 = 0.0%).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 533
Age Range See abstract
Condition diabetes

MeSH Terms

  • Pregnancy
  • Female
  • Humans
  • Diabetes, Gestational
  • Blood Glucose
  • Yogurt
  • Probiotics
  • Fasting

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: probiotics

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09