Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies

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#humans #magnesium #fractures-bone #bone-and-bones #incidence

Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies

Dominguez et al., 2023 | Nutrients | Meta Analysis

Citation

Dominguez Ligia J, Veronese Nicola, ... Barbagallo Mario. Association between Serum Magnesium and Fractures: A Systematic Review and Meta-Analysis of Observational Studies. Nutrients. 2023-Mar-07;15(6). doi:10.3390/nu15061304

Abstract

Magnesium, an essential cation for numerous cellular processes, is a major component of bone. However, its relationship with the risk of fractures is still uncertain. The present systematic review and meta-analysis aim to investigate the impact of serum Mg on the risk of incident fractures. A systematic search was conducted using several databases including PubMed/Medline and Scopus from inception to 24 May 2022, including observational studies investigating serum Mg and the incidence of fractures considered as outcomes. Abstract and full-text screenings, data extractions, and risk of bias assessments were conducted by two investigators independently. Any inconsistencies were resolved by consensus with a third author. The Newcastle-Ottawa Scale was used to assess the study quality/risk of bias. Among 1332 records initially screened, 16 were retrieved as full-texts; of them, four papers were included in the systematic review with a total of 119,755 participants. We found that lower serum Mg concentrations were associated with a significantly higher risk of incident fractures (RR = 1.579; 95%CI: 1.216-2.051; p = 0.001; I2 = 46.9%). Our systematic review with meta-analysis suggests a strong association of serum Mg concentrations with incident fractures. Further research is needed to confirm our results among other populations and to assess whether serum Mg is potentially relevant in the prevention of fractures, which continue to increase and represent a significant health burden due to the associated disability.

Key Findings

Further research is needed to confirm our results among other populations and to assess whether serum Mg is potentially relevant in the prevention of fractures, which continue to increase and represent a significant health burden due to the associated disability.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 119755
Age Range See abstract
Condition See abstract

MeSH Terms

  • Humans
  • Magnesium
  • Fractures, Bone
  • Bone and Bones
  • Incidence

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Meta-Analysis, Systematic Review, Journal Article
  • Vertical: magnesium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09