The role of nicotinic receptors in alcohol consumption

Kamens et al., 2023 | Pharmacol Res | Systematic Review

Citation

Kamens Helen M, Flarend Geneva, Horton William J. The role of nicotinic receptors in alcohol consumption. Pharmacol Res. 2023-Apr;190:106705. doi:10.1016/j.phrs.2023.106705

Abstract

The use of alcohol causes significant morbidity and mortality across the globe. Alcohol use disorder (AUD) is defined by the excessive use of this drug despite a negative impact on the individual's life. While there are currently medications available to treat AUD, they have limited efficacy and several side effects. As such, it is essential to continue to look for novel therapeutics. One target for novel therapeutics is nicotinic acetylcholine receptors (nAChRs). Here we systematically review the literature on the involvement of nAChRs in alcohol consumption. Data from both genetic and pharmacology studies provide evidence that nAChRs modulate alcohol intake. Interestingly, pharmacological modulation of all nAChR subtypes examined can decrease alcohol consumption. The reviewed literature demonstrates that nAChRs should continue to be investigated as novel therapeutics for AUD.

Key Findings

The reviewed literature demonstrates that nAChRs should continue to be investigated as novel therapeutics for AUD.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	See abstract

MeSH Terms

Humans
Alcohol Drinking
Alcoholism
Ethanol
Nicotinic Agonists
Nicotinic Antagonists
Receptors, Nicotinic

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Research Support, N.I.H., Extramural, Systematic Review
Vertical: niacin

Provenance

PMID: 36813094
DOI: 10.1016/j.phrs.2023.106705
PMCID: PMC10083870
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09