The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review

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#female #humans #postmenopause #menopause #hot-flashes

The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review

Feduniw et al., 2022 | Nutrients | Systematic Review

Citation

Feduniw Stepan, Korczyńska Lidia, ... Ciebiera Michał. The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review. Nutrients. 2022-Dec-29;15(1). doi:10.3390/nu15010160

Abstract

Menopause is a physiological change in any woman. Nevertheless, its symptoms could be difficult to accept, and hormone therapy can be sometimes unattractive or contraindicated. Vitamin E components are phytoestrogens, so they are believed to be useful in some indications including menopause. This review aimed to assess the available evidence on the effectiveness of vitamin E in alleviating menopausal symptoms. The Pubmed/MEDLINE, Cochrane Library and Scopus databases were screened. All types of studies that assessed the effectiveness of vitamin E in alleviating menopausal symptoms were included. The PICO question was: "How does vitamin E supplementation affect menopausal symptom occurrence?" The PROSPERO ID number of this review is CRD42022328830. After quality assessment, 16 studies were included in the analysis. The studies were divided into three groups in which the influence of vitamin E on the genital syndrome of menopause, vasomotor symptoms and vascular and metabolic changes were assessed. Vitamin E influences postmenopausal hot flashes, vascular modulation, plasma lipid profile level and vaginal changes. Compared to vitamin E, estrogen administration leads to better clinical effects. Nevertheless, vitamin E might serve as additive to hormone therapy and its alternative in women with contraindications to estrogens. More quality data are necessary to draw final conclusions.

Key Findings

More quality data are necessary to draw final conclusions.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 16
Age Range See abstract
Condition See abstract

MeSH Terms

  • Female
  • Humans
  • Postmenopause
  • Menopause
  • Hot Flashes
  • Estrogens
  • Dietary Supplements
  • Vitamin E

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09