Pharmacological prevention strategy for capecitabine-induced hand-foot syndrome: A network meta-analysis of randomized control trials
Pharmacological prevention strategy for capecitabine-induced hand-foot syndrome: A network meta-analysis of randomized control trials
Kao et al., 2022 | Dermatol Ther | Other
Citation
Kao Yung-Shuo, Lo Chen-Hsu, ... Hung Cheng-Hsien. Pharmacological prevention strategy for capecitabine-induced hand-foot syndrome: A network meta-analysis of randomized control trials. Dermatol Ther. 2022-Oct;35(10):e15774. doi:10.1111/dth.15774
Abstract
Capecitabine-induced hand-foot syndrome (HFS) is common in clinical practice. There are many regimens used to prevent HFS. However, the most effective preventive regimen has not yet been identified. Thus, we conducted a network meta-analysis to investigate the best preventive regimen for HFS. The PRISMA-NMA guidelines were used in this study. The PubMed, Cochrane, and Embase databases were searched. The main endpoint was set as HFS of National Cancer Institute grade 2 or more. We included only randomized control trials. The P-score was used to rank the regimens. Among all the regimens, topical silymarin had the best preventive ability compared with the placebo (OR: 0.08; 95% CI: 0.01-0.71). The other identified effective regimen included pyridoxine (400 mg) and celecoxib; compared with the placebo, the odds ratio was 0.27 (95% CI: 0.08-0.91) and 0.41 (95% CI: 0.18-0.95), respectively. Topical silymarin is the most useful regimen for preventing capecitabine-induced HFS.
Key Findings
Topical silymarin is the most useful regimen for preventing capecitabine-induced HFS.
Outcomes Measured
- Requires manual extraction
Population
| Field | Value |
|---|---|
| Population | See abstract |
| Sample Size | See abstract |
| Age Range | See abstract |
| Condition | See abstract |
MeSH Terms
- Antimetabolites, Antineoplastic
- Capecitabine
- Celecoxib
- Hand-Foot Syndrome
- Humans
- Pyridoxine
- Randomized Controlled Trials as Topic
- Silymarin
Evidence Classification
- Level: Other
- Publication Types: Journal Article, Network Meta-Analysis
- Vertical: vitamin-b6
Provenance
- PMID: 36054263
- DOI: 10.1111/dth.15774
- PMCID: Not in PMC
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09