Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials

source extracted confidence: high 2026-04-09
#dietary-supplements #fibrinogen #humans #intercellular-adhesion-molecule-1 #plasminogen-activator-inhibitor-1

Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials

Mohammadipoor et al., 2022 | Phytother Res | Meta Analysis

Citation

Mohammadipoor Nazanin, Shafiee Fatemeh, ... Pour Abbasi Mohammad Sadegh. Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2022-Sep;36(9):3529-3539. doi:10.1002/ptr.7562

Abstract

We perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to quantify the effect of resveratrol supplementation on endothelial function. A comprehensive search was performed in electronic databases including PubMed, Scopus, Web of Science, and Cochrane Library up to February 2021 with no limitation in time and language. A meta-analysis of eligible studies was performed using a random-effects model to estimate the pooled effect size of flow-mediated dilation (FMD), intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), fibrinogen, and plasminogen activator inhibitor-1 (PAI-1). In total, 21 arms from 17 studies were included. The meta-analysis results showed that resveratrol significantly change the concentrations of FMD (WMD: 1.43%; 95% CI: 0.98 to 1.88, p < .001) and ICAM-1 (WMD: -7.09 ng/ml, 95% CI: -7.45 to -6.73, p < .001). However, VCAM-1, fibrinogen, and PAI-1 did not change significantly after resveratrol supplementation. In conclusion, the results of this study suggest that resveratrol supplementation can improve endothelial function which could be important, especially in patients with cardiovascular diseases.

Key Findings

In conclusion, the results of this study suggest that resveratrol supplementation can improve endothelial function which could be important, especially in patients with cardiovascular diseases.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population cardiovascular diseases
Sample Size 17
Age Range See abstract
Condition See abstract

MeSH Terms

  • Dietary Supplements
  • Fibrinogen
  • Humans
  • Intercellular Adhesion Molecule-1
  • Plasminogen Activator Inhibitor 1
  • Randomized Controlled Trials as Topic
  • Resveratrol
  • Vascular Cell Adhesion Molecule-1

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09