Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#adult #dietary-supplements #fatigue #humans #panax

Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis

Zhu et al., 2022 | Medicine (Baltimore) | Meta Analysis

Citation

Zhu Jianxun, Xu Xiaoru, ... Wang Zhihong. Efficacy of ginseng supplements on disease-related fatigue: A systematic review and meta-analysis. Medicine (Baltimore). 2022-Jul-01;101(26):e29767. doi:10.1097/MD.0000000000029767

Abstract

BACKGROUND: Ginseng has been believed to provide energy, physical health, and well-being to patients for hundreds of years. Fatigue is a multidimensional symptom with unknown etiology and varying severity, and lots of patients suffer from fatigue. METHODS: We search for research of ginseng treatment of disease-related fatigue in adult patients in Pubmed, Embase, Medline, and Cochrane library. Two independent reviewers assessed included studies and met to develop consensus on included studies. And we used Review Manager 5.3 software to evaluate the risk of bias. RESULTS: The present meta-analysis included 12 randomized controlled trial containing 1298 patients. In the fixed-effect meta-analysis of 12 randomized controlled trial, ginseng supplements had a statistically significant efficacy on disease-related fatigue reduction (standardized mean difference = 0.33, 95% confidence interval = 0.44-0.22). CONCLUSIONS: The use of ginseng supplements is benefit for patients to reduce disease-related fatigue.

Key Findings

The present meta-analysis included 12 randomized controlled trial containing 1298 patients. In the fixed-effect meta-analysis of 12 randomized controlled trial, ginseng supplements had a statistically significant efficacy on disease-related fatigue reduction (standardized mean difference = 0.33, 95% confidence interval = 0.44-0.22).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population adult patients
Sample Size 1298
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Dietary Supplements
  • Fatigue
  • Humans
  • Panax
  • Randomized Controlled Trials as Topic

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09