The bioactivities of resveratrol and its naturally occurring derivatives on skin

source extracted confidence: high 2026-04-09
#animals #antioxidants #cosmetics #resveratrol #skin

The bioactivities of resveratrol and its naturally occurring derivatives on skin

Lin et al., 2021 | J Food Drug Anal | Systematic Review

Citation

Lin Ming-Hsien, Hung Chi-Feng, ... Fang Jia-You. The bioactivities of resveratrol and its naturally occurring derivatives on skin. J Food Drug Anal. 2021-Mar-15;29(1):15-38. doi:10.38212/2224-6614.1151

Abstract

Resveratrol has been extensively reported as a potential compound to treat some skin disorders, including skin cancer, photoaging, allergy, dermatitis, melanogenesis, and microbial infection. There has been an increasing interest in the discovery of cosmetic application using resveratrol as the active ingredient because of its anti-aging and skin lightening activities. The naturally occurring derivatives of resveratrol also exert a beneficial effect on the skin. There are four groups of resveratrol derivatives, including hydroxylated compounds, methoxylated compounds, glycosides, and oligomers. The major mechanism of resveratrol and its derivatives for attenuating cutaneous neoplasia, photoaging and inflammation, are related with its antioxidative activity to scavenge hydroxyl radical, nitric oxide and superoxide anion. A systematic review was conducted to describe the association between resveratrol-related compounds and their benefits on the skin. Firstly, the chemical classification of resveratrol and its derivatives was introduced. In this review the cases which were treated for different skin conditions by resveratrol and the derivatives were also described. The use of nanocarriers for efficient resveratrol skin delivery is also introduced here. This review summarizes the cutaneous application of resveratrol and the related compounds as observed in the cell-based, animal-based and clinical models. The research data in the present study relates to the management of resveratrol for treating skin disorders and suggesting a way forward to achieve advancement in using it for cosmetic and dermatological purpose.

Key Findings

The research data in the present study relates to the management of resveratrol for treating skin disorders and suggesting a way forward to achieve advancement in using it for cosmetic and dermatological purpose.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition inflammation

MeSH Terms

  • Animals
  • Antioxidants
  • Cosmetics
  • Resveratrol
  • Skin
  • Skin Diseases
  • Stilbenes

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review, Research Support, Non-U.S. Gov't
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09