Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

source extracted confidence: high 2026-04-09
#adolescent #adult #amidohydrolases #carbon-nitrogen-ligases-with-glutamine-as-amide-n-donor #child

Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence

Najjar et al., 2021 | Nutrients | Meta Analysis

Citation

Najjar Liana, Sutherland Joshua, ... Hyppönen Elina. Vitamin D and Type 1 Diabetes Risk: A Systematic Review and Meta-Analysis of Genetic Evidence. Nutrients. 2021-Nov-26;13(12). doi:10.3390/nu13124260

Abstract

Several observational studies have examined vitamin D pathway polymorphisms and their association with type 1 diabetes (T1D) susceptibility, with inconclusive results. We aimed to perform a systematic review and meta-analysis assessing associations between selected variants affecting 25-hydroxyvitamin D [25(OH)D] and T1D risk. We conducted a systematic search of Medline, Embase, Web of Science and OpenGWAS updated in April 2021. The following keywords "vitamin D" and/or "single nucleotide polymorphisms (SNPs)" and "T1D" were selected to identify relevant articles. Seven SNPs (or their proxies) in six genes were analysed: CYP2R1 rs10741657, CYP2R1 (low frequency) rs117913124, DHCR7/NADSYN1 rs12785878, GC rs3755967, CYP24A1 rs17216707, AMDHD1 rs10745742 and SEC23A rs8018720. Seven case-control and three cohort studies were eligible for quantitative synthesis (n = 10). Meta-analysis results suggested no association with T1D (range of pooled ORs for all SNPs: 0.97-1.02; p > 0.01). Heterogeneity was found in DHCR7/NADSYN1 rs12785878 (I2: 64.8%, p = 0.02). Sensitivity analysis showed exclusion of any single study did not alter the overall pooled effect. No association with T1D was observed among a Caucasian subgroup. In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.

Key Findings

In conclusion, the evidence from the meta-analysis indicates a null association between selected variants affecting serum 25(OH)D concentrations and T1D.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 10
Age Range See abstract
Condition diabetes

MeSH Terms

  • Adolescent
  • Adult
  • Amidohydrolases
  • Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor
  • Child
  • Child, Preschool
  • Cholestanetriol 26-Monooxygenase
  • Cohort Studies
  • Cytochrome P450 Family 2
  • Diabetes Mellitus, Type 1
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Oxidoreductases Acting on CH-CH Group Donors
  • Polymorphism, Single Nucleotide
  • Receptors, Calcitriol
  • Vesicular Transport Proteins
  • Vitamin D
  • Vitamin D Deficiency
  • Vitamin D-Binding Protein
  • Vitamin D3 24-Hydroxylase
  • Young Adult

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09