Association between magnesium concentrations and prediabetes: a systematic review and meta-analysis
Association between magnesium concentrations and prediabetes: a systematic review and meta-analysis
Ebrahimi et al., 2021 | Sci Rep | Meta Analysis
Citation
Ebrahimi Mousavi Sara, Ghoreishy Seyed Mojtaba, ... Mohammadi Hamed. Association between magnesium concentrations and prediabetes: a systematic review and meta-analysis. Sci Rep. 2021-Dec-22;11(1):24388. doi:10.1038/s41598-021-03915-3
Abstract
Studies on the association between serum magnesium level and prediabetes yielded inconsistent results. Therefore, the present meta-analysis was designed to examine the association between serum magnesium levels and prediabetes. Online databases including PubMed, Embase, Scopus and Google Scholar were searched up to October, 2020. A total of 10 studies that reported mean and standard deviation (SD) of magnesium levels in prediabetes and healthy control group were identified. Random effects models were used to pool weighted mean differences (WMDs) of serum magnesium levels. Pooled-analysis showed that subjects with prediabetes had significantly lower serum magnesium levels compared with healthy controls (WMD = - 0.07 mmol/L; 95% CI - 0.09, - 0.05 mmol/L, P < 0.001). A significant heterogeneity observed across included studies (I2 = 95.6%, P < 0.001). However, different subgroup analysis did not detect the potential source of observed heterogeneity. Withdrawal of each individual study had no effect on the overall results. The present meta-analysis showed that circulating magnesium levels in people with prediabetes were significantly lower than healthy controls, confirming that magnesium deficiency may play a role in development and progression of prediabetes. Further studies with larger sample size and robust design are warranted to confirm present results.
Key Findings
Further studies with larger sample size and robust design are warranted to confirm present results.
Outcomes Measured
- serum magnesium levels
Population
| Field | Value |
|---|---|
| Population | prediabetes had significantly lower |
| Sample Size | 10 |
| Age Range | See abstract |
| Condition | diabetes |
MeSH Terms
- Humans
- Magnesium
- Magnesium Deficiency
- Prediabetic State
Evidence Classification
- Level: Meta Analysis
- Publication Types: Journal Article, Meta-Analysis, Systematic Review
- Vertical: magnesium
Provenance
- PMID: 34937856
- DOI: 10.1038/s41598-021-03915-3
- PMCID: PMC8695575
- Verified: 2026-04-09 via PubMed E-utilities API
Source extracted via PubMed E-utilities API on 2026-04-09