The Dichotomous Effect of Thiamine Supplementation on Tumorigenesis: A Systematic Review

source extracted confidence: high 2026-04-09
#carcinogenesis #cell-transformation-neoplastic #dietary-supplements #humans #neoplasms

The Dichotomous Effect of Thiamine Supplementation on Tumorigenesis: A Systematic Review

Queiroz et al., 2022 | Nutr Cancer | Systematic Review

Citation

Queiroz Júnior José Reginaldo Alves de, Costa Pereira Jarson Pedro da, ... Maia Carina Scanoni. The Dichotomous Effect of Thiamine Supplementation on Tumorigenesis: A Systematic Review. Nutr Cancer. 2022;74(6):1942-1957. doi:10.1080/01635581.2021.2007962

Abstract

The malignant neoplastic cell is characterized by its diverse metabolic changes. It occurs in order to maintain the high rate of proliferation. The possibility of new pharmacological targets has inserted tumor metabolism as a target for recent research, emphasizing the enzymatic activity of thiamin. This review aims to elucidate the behavior of thiamin against tumor development. This is a systematic review in which studies indexed in Pubmed, Scopus, SciELO and BVS were searched using the descriptors (Thiamin OR Vitamin B1) AND (Cancer OR Malignant neoplasia) AND (Tumor metabolism). Title and abstract were read. Duplicates, literary reviews, books, conference abstracts, editorials, and papers published prior to 2010 were eliminated. 23 records were included in this review. Low doses of thiamin have been shown to be enough to stimulate tumor growth. Another population studies has shown evidence of tumor regression after correction of vitamin B1 deficiency. There is an open path for the development of new research to better assess the influence of thiamin on cancer cells. Once the connections between thiamin and the metabolism of cancer cells are fully established, new opportunities for therapeutic intervention and dietary modification will appear to reduce the progression of the disease in patients with cancer.

Key Findings

Once the connections between thiamin and the metabolism of cancer cells are fully established, new opportunities for therapeutic intervention and dietary modification will appear to reduce the progression of the disease in patients with cancer.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population cancer
Sample Size See abstract
Age Range See abstract
Condition deficiency

MeSH Terms

  • Carcinogenesis
  • Cell Transformation, Neoplastic
  • Dietary Supplements
  • Humans
  • Neoplasms
  • Thiamine
  • Thiamine Deficiency

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: thiamine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09