Diet Therapeutics Interventions for Obesity: A Systematic Review and Network Meta-Analysis

source extracted confidence: high 2026-04-09
#diet #humans #obesity #overweight #weight-loss

Diet Therapeutics Interventions for Obesity: A Systematic Review and Network Meta-Analysis

Morsali et al., 2021 | J Res Health Sci | Systematic Review

Citation

Morsali Mina, Poorolajal Jalal, ... Doosti-Irani Amin. Diet Therapeutics Interventions for Obesity: A Systematic Review and Network Meta-Analysis. J Res Health Sci. 2021-Sep-19;21(3):e00521. doi:10.34172/jrhs.2021.63

Abstract

BACKGROUND: Up to now, different diet therapeutics interventions have been introduced for the treatment of obesity. The present study aimed to compare the diet therapeutics interventions for obesity simultaneously. STUDY DESIGN: Systematic review and network meta-analysis METHODS: The major international databases, including Medline (via PubMed), Web of Science, Scopus, Cochrane Library, and Embase, were searched using a predesigned search strategy. Randomized controlled trials (RCTs) that had compared the diet therapy interventions were included. The mean difference with a 95% confidence interval was used to summarize the effect size in the network meta-analysis. The frequentist approach was used for data analysis. RESULTS: In total, 36 RCTs out of 9335 retrieved references met the inclusion criteria in this review. The included RCTs formed nine independent networks. Based on the results, Hypocaloricdiet+Monoselect Camellia (MonCam, P=0.99), energy restriction, behavior modification+exercise (LED) (P=0.99), sweetener at 20% of total calories (HFCS20)+Ex (P=0.67), catechin-richgreentea(650)+inulin (P=0.68), very low calorie diet (VLCD) (P=1.00), normal protein diet+resistance exercise (NPD+RT) (P=0.80), low-calorie diets+exercise (Hyc+Ex) (P=0.85), high-soy-protein low-fat diet (SD) (P=0.75), calorie restriction+behavioral weight loss (Hyc+BWL) (P=0.99) were the better treatments for weight loss in the networks one to nine, respectively. CONCLUSION: Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.

Key Findings

In total, 36 RCTs out of 9335 retrieved references met the inclusion criteria in this review. The included RCTs formed nine independent networks. Based on the results, Hypocaloricdiet+Monoselect Camellia (MonCam, P=0.99), energy restriction, behavior modification+exercise (LED) (P=0.99), sweetener at 20% of total calories (HFCS20)+Ex (P=0.67), catechin-richgreentea(650)+inulin (P=0.68), very low calorie diet (VLCD) (P=1.00), normal protein diet+resistance exercise (NPD+RT) (P=0.80), low-calorie

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population overweight and obesity
Sample Size 36
Age Range See abstract
Condition See abstract

MeSH Terms

  • Diet
  • Humans
  • Obesity
  • Overweight
  • Weight Loss

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review, Network Meta-Analysis
  • Vertical: green-tea

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09