A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review

Najafi et al., 2021 | Diabetes Metab Syndr | Systematic Review

Citation

Najafi Marziyeh, Nikpayam Omid, ... Sohrab Golbon. A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review. Diabetes Metab Syndr. 2021;15(5):102224. doi:10.1016/j.dsx.2021.102224

Abstract

BACKGROUND AND AIMS: Silent information regulator 1 (Sirt1) involved in histone stability, transcriptional activity, and translocation. This systematic review aimed to summarize the effects of Resveratrol on Sirt1 expression. MATERIALS AND METHODS: Electronic databases including Scopus, Medline and web of knowledge were searched up to March 2020. RESULTS: Out of 801 studies identified in our search finally 12 articles included. Totally six studies evaluated the effects of resveratrol on SIRT1 gene expression, and six articles investigate protein expression. CONCLUSION: The results of the included studies showed that resveratrol supplementation had beneficial effects on protein and gene expression of SIRT1.

Key Findings

Out of 801 studies identified in our search finally 12 articles included. Totally six studies evaluated the effects of resveratrol on SIRT1 gene expression, and six articles investigate protein expression.

Outcomes Measured

Requires manual extraction

Population

Field	Value
Population	See abstract
Sample Size	801
Age Range	See abstract
Condition	See abstract

MeSH Terms

Antioxidants
Diabetes Mellitus
Dietary Supplements
Gene Expression Regulation
Humans
Inflammation
Obesity
Prognosis
Resveratrol
Sirtuin 1

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Systematic Review
Vertical: resveratrol

Provenance

PMID: 34403949
DOI: 10.1016/j.dsx.2021.102224
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09