Can grape polyphenols affect glycation markers? A systematic review

source extracted confidence: high 2026-04-09
#polyphenols #maillard-reaction #vitis #magnesium-oxide #resveratrol

Can grape polyphenols affect glycation markers? A systematic review

Coelho et al., 2023 | Crit Rev Food Sci Nutr | Systematic Review

Citation

Coelho Olívia G L, Ribeiro Priscila V M, Alfenas Rita de Cássia G. Can grape polyphenols affect glycation markers? A systematic review. Crit Rev Food Sci Nutr. 2023;63(9):1208-1218. doi:10.1080/10408398.2021.1962796

Abstract

Advanced glycation end-products (AGEs) favor inflammation and oxidative stress, playing a role in chronic diseases pathogenesis. Grape polyphenols exert antiglycative and antioxidant effects which may contribute to prevent chronic diseases. However, clinical evidence of grape polyphenols on chronic disease prevention and treatment by glycation markers modulation are limited. Therefore, we aimed to critically analyze studies about that topic to investigate the antiglycative power of dietary grape polyphenol, and to explore the molecular mechanism involved. This systematic review was conducted and reported according to PRISMA guidelines. The following search terms were used: "grape", "extract", "grape seed extract", "grape skin extract", "polyphenol extract", "grape polyphenol(s)", "grape juice", "resveratrol", "quercetin", "catechin", "epicatechin", "procyanidin(s)", and "anthocyanin(s)". Seven studies were included. Glycated hemoglobin was not affected. The interventions duration may not have been enough to detect changes. Grape polyphenols reduced fructosamine and methylglyoxal (MGO) concentrations, and increased endogenous secretory RAGE (esRAGE) gene expression but did not affect the serum concentration. Resveratrol antiglycative effects are mainly due its ability to trap MGO and downregulate RAGE. In conclusion, grape polyphenols may have a positive impact on early glycation products, AGEs and esRAGE. Future studies are needed to explore how they modulate AGEs and receptors in chronic diseases.

Key Findings

Future studies are needed to explore how they modulate AGEs and receptors in chronic diseases.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Polyphenols
  • Maillard Reaction
  • Vitis
  • Magnesium Oxide
  • Resveratrol
  • Glycation End Products, Advanced

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Systematic Review, Journal Article
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09