Vitamin D and asthma occurrence in children: A systematic review and meta-analysis

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Vitamin D and asthma occurrence in children: A systematic review and meta-analysis

Wang et al., 2022 | J Pediatr Nurs | Meta Analysis

Citation

Wang Qiong, Ying Qinlai, ... Chen Junguo. Vitamin D and asthma occurrence in children: A systematic review and meta-analysis. J Pediatr Nurs. 2022;62:e60-e68. doi:10.1016/j.pedn.2021.07.005

Abstract

PROBLEM: The association between serum 25-Hydroxyvitamin D (25-OHD) level and asthma occurrence in children was controversial. ELIGIBILITY CRITERIA: The Pubmed, Ovid Medline, Embase, Cochrane Library were systematically searched up to April 13th 2020. All the study measured the serum 25-OHD level in children, or classified the children based on the 25-OHD level into severe vitamin D deficiency, insufficient deficiency and comparing the prevalence of asthma in childhood were included in our study. SAMPLE: A total of 35 studies were included in our meta-analysis. Among them, 24 studies were included for analyzing the association between 25-OHD level and asthma, and 12 studies evaluated the treatment effect of vitamin D. RESULTS: The children with asthma (5711 participants) had significant lower 25-OHD level than children without asthma (21,561 participants) (21.7 ng/ml versus 26.5 ng/ml, SMD = -1.36, 95% = -2.40--0.32, P = 0.010). Besides, the children with asthma treated with vitamin D supplement had a significantly lower recurrence rate than the placebo group (18.4% versus 35.9%, RR = 0.35, 95%CI = 0.35-0.79, P = 0.002). CONCLUSIONS: Children with asthma had a lower 25-OHD level than healthy children. Vitamin D supplement could decrease the asthma recurrence rate in the follow-up years. IMPLICATIONS: This study implies that lower 25-OHD may cause asthma in childhood.

Key Findings

The children with asthma (5711 participants) had significant lower 25-OHD level than children without asthma (21,561 participants) (21.7 ng/ml versus 26.5 ng/ml, SMD = -1.36, 95% = -2.40--0.32, P = 0.010). Besides, the children with asthma treated with vitamin D supplement had a significantly lower recurrence rate than the placebo group (18.4% versus 35.9%, RR = 0.35, 95%CI = 0.35-0.79, P = 0.002).

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 5711
Age Range See abstract
Condition deficiency

MeSH Terms

  • Asthma
  • Child
  • Dietary Supplements
  • Humans
  • Vitamin D
  • Vitamin D Deficiency

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-d

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09