A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy

source extracted confidence: high 2026-04-09
#enzyme-activators #humans #muscle-skeletal #muscular-dystrophy-duchenne #resveratrol

A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy

Domi et al., 2021 | Cells | Systematic Review

Citation

Domi Elisa, Hoxha Malvina, ... Zappacosta Bruno. A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy. Cells. 2021-Jun-03;10(6). doi:10.3390/cells10061380

Abstract

Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting.

Key Findings

Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Enzyme Activators
  • Humans
  • Muscle, Skeletal
  • Muscular Dystrophy, Duchenne
  • Resveratrol
  • Sirtuin 1

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09