Effects of chromium supplementation on oxidative stress biomarkers

source extracted confidence: high 2026-04-09
#antioxidants #thiobarbituric-acid-reactive-substances #oxidative-stress #biomarkers #glutathione-peroxidase

Effects of chromium supplementation on oxidative stress biomarkers

Amini et al., 2023 | Int J Vitam Nutr Res | Meta Analysis

Citation

Amini Mohammad Reza, Sheikhhossein Fatemeh, ... Shab-Bidar Sakineh. Effects of chromium supplementation on oxidative stress biomarkers. Int J Vitam Nutr Res. 2023-Jun;93(3):241-251. doi:10.1024/0300-9831/a000706

Abstract

Aim: This systematic review and meta-analysis aimed to evaluate the effects of chromium supplementation on oxidative stress biomarkers such as superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPX), malondialdehyde (MDA), total antioxidant status (TAS), thiobarbituric acid reactive substances (TBARS), catalase (CAT), nitric oxide (NO), total antioxidant capacity (TAC) and protein carbonyl. Methods: Relevant studies, published from inception until July 2019, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. All randomized clinical trials investigating the effect of chromium supplementation on oxidative stress were included. Results: Out of 252 citations, 10 trials that enrolled 595 subjects were included. Chromium supplementation resulted in a significant increase in GSH (WMD: 64.79 mg/dl, 95% CI: 22.43 to 107.15; P=0.003) but no significant change in MDA, TAS, TBARS levels, SOD, CAT levels and GPX. Chromium picolinate supplementation resulted in a significant increase in TAC while failing to have a significant effect on NO. Moreover, both chromium picolinate and chromium dinicocysteinate supplementation reduced protein carbonyl levels. Conclusion: Overall, this meta-analysis demonstrated that chromium supplementation increased GSH without any significant changes in the mean of GPX, MDA, TAS, TBARS, CAT and SOD.

Key Findings

Out of 252 citations, 10 trials that enrolled 595 subjects were included. Chromium supplementation resulted in a significant increase in GSH (WMD: 64.79 mg/dl, 95% CI: 22.43 to 107.15; P=0.003) but no significant change in MDA, TAS, TBARS levels, SOD, CAT levels and GPX. Chromium picolinate supplementation resulted in a significant increase in TAC while failing to have a significant effect on NO. Moreover, both chromium picolinate and chromium dinicocysteinate supplementation reduced protein car

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 595
Age Range See abstract
Condition stress

MeSH Terms

  • Antioxidants
  • Thiobarbituric Acid Reactive Substances
  • Oxidative Stress
  • Biomarkers
  • Glutathione Peroxidase
  • Dietary Supplements
  • Superoxide Dismutase

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Systematic Review, Meta-Analysis, Journal Article
  • Vertical: chromium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09