Clinical trials with plants in diabetes mellitus therapy: a systematic review

source extracted confidence: high 2026-04-09
#blood-glucose #diabetes-mellitus #humans #hypoglycemic-agents #insulin-resistance

Clinical trials with plants in diabetes mellitus therapy: a systematic review

Marmitt et al., 2021 | Expert Rev Clin Pharmacol | Systematic Review

Citation

Marmitt Diorge Jonatas, Shahrajabian Mohamad Hesam, ... Rempel Claudete. Clinical trials with plants in diabetes mellitus therapy: a systematic review. Expert Rev Clin Pharmacol. 2021-Jun;14(6):735-747. doi:10.1080/17512433.2021.1917380

Abstract

INTRODUCTION: The chronic metabolic disorder diabetes mellitus is a fast-growing global problem with huge social, health, and economic consequences, having one of the highest morbidities and mortality rates. Prolonged use of many available medications can produce undesirable side effects. Thus, plants appear as an important source of bioactive resources for the discovery of new treatments for diabetes. AREAS COVERED: In this sense, this systematic review focused on clinical trials involving plants of National List of Medicinal Plants of Interest to the Unified Health System (RENISUS) (or compounds) with antidiabetic properties. We analyzed indexed studies in PubMed following the reporting guidelines of PRISMA. EXPERT OPINION: Of the 51 clinical trials found, Curcuma longa, Glycine max, Zingiber officinale, Punica granatum, Aloe vera, Momordica charantia are the species with the greatest amount of clinical trials and the attenuation of insulin resistance, decreased fasting blood glucose and glycosylated hemoglobin levels are some of the main mechanisms by which these plants exert hypoglycemic effects. Thus, we speculate that the Clinical Pharmacology should explore the field of plant-based compounds that will keep concentrating the attention of researchers, and therefore, we gathered studies in advanced stages that highlight the role of plants in the diabetes therapy.

Key Findings

Thus, we speculate that the Clinical Pharmacology should explore the field of plant-based compounds that will keep concentrating the attention of researchers, and therefore, we gathered studies in advanced stages that highlight the role of plants in the diabetes therapy.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Blood Glucose
  • Diabetes Mellitus
  • Humans
  • Hypoglycemic Agents
  • Insulin Resistance
  • Phytotherapy
  • Plant Preparations
  • Plants, Medicinal

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: ginger

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09