Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review

Gruendler et al., 2020 | Molecules | Systematic Review

Citation

Gruendler Reinhard, Hippe Berit, ... Haslberger Alexander G. Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer's Disease: A Systematic Review. Molecules. 2020-Dec-18;25(24). doi:10.3390/molecules25246018

Abstract

Aging and the emergence of age-associated illnesses are one of the major challenges of our present society. Alzheimer's disease (AD) is closely associated with aging and is defined by increasing memory loss and severe dementia. Currently, there are no therapy options available that halt AD progression. This work investigates three hallmarks of the disease (autophagy, neuroinflammation, and senescence) and systematically analyzes if there is a beneficial effect from three substances derived from food sources, the so called "nutraceuticals" epigallocatechin gallate, fisetin, and spermidine, on these hallmarks. The results imply a positive outlook for the reviewed substances to qualify as a novel treatment option for AD. A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD.

Key Findings

A combination of nutraceutical substances and other preventive measures could have significant clinical impact in a multi-layered therapy approach to counter AD.

Outcomes Measured

• Requires manual extraction

Population

MeSH Terms

• Alzheimer Disease
• Animals
• Autophagy
• Catechin
• Cellular Senescence
• Dietary Supplements
• Flavonols
• Humans
• Inflammation
• Spermidine

Evidence Classification

• Level: Systematic Review
• Publication Types: Journal Article, Systematic Review
• Vertical: green-tea

Provenance

• PMID: 33353228
• DOI: 10.3390/molecules25246018
• PMCID: PMC7765980
• Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09