Myositis and acute kidney injury in bacterial atypical pneumonia: Systematic literature review

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Myositis and acute kidney injury in bacterial atypical pneumonia: Systematic literature review

Simoni et al., 2020 | J Infect Public Health | Systematic Review

Citation

Simoni Chiara, Camozzi Pietro, ... Milani Gregorio P. Myositis and acute kidney injury in bacterial atypical pneumonia: Systematic literature review. J Infect Public Health. 2020-Dec;13(12):2020-2024. doi:10.1016/j.jiph.2020.10.007

Abstract

BACKGROUND: Bacterial community-acquired atypical pneumonia is sometimes complicated by a myositis or by a renal parenchymal disease. Available reviews do not mention the concurrent occurrence of both myositis and acute kidney injury. METHODS: In order to characterize the link between bacterial community-acquired atypical pneumonia and both myositis and a renal parenchymal disease, we reviewed the literature (United States National Library of Medicine and Excerpta Medica databases). RESULTS: We identified 42 previously healthy subjects (35 males and 7 females aged from 2 to 76, median 42 years) with a bacterial atypical pneumonia associated both with myositis (muscle pain and creatine kinase ≥5 times the upper limit of normal) and acute kidney injury (increase in creatinine to ≥1.5 times baseline or increase by ≥27 μmol/L above the upper limit of normal). Thirty-six cases were caused by Legionella species (N = 27) and by Mycoplasma pneumoniae (N = 9). Further germs accounted for the remaining 6 cases. The vast majority of cases (N = 36) presented a diffuse myalgia. Only a minority of cases (N = 3) were affected by a calf myositis. The diagnosis of rhabdomyolysis-associated kidney injury was retained in 37 and that of acute interstitial nephritis in the remaining 5 cases. CONCLUSION: Bacterial atypical pneumonia may occasionally induce myositis and secondary kidney damage.

Key Findings

We identified 42 previously healthy subjects (35 males and 7 females aged from 2 to 76, median 42 years) with a bacterial atypical pneumonia associated both with myositis (muscle pain and creatine kinase ≥5 times the upper limit of normal) and acute kidney injury (increase in creatinine to ≥1.5 times baseline or increase by ≥27 μmol/L above the upper limit of normal). Thirty-six cases were caused by Legionella species (N = 27) and by Mycoplasma pneumoniae (N = 9). Further germs accounted for the

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 27
Age Range See abstract
Condition See abstract

MeSH Terms

  • Acute Kidney Injury
  • Adult
  • Community-Acquired Infections
  • Female
  • Humans
  • Male
  • Myositis
  • Nephritis, Interstitial
  • Pneumonia, Bacterial
  • Pneumonia, Mycoplasma

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: creatine

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09