Panax notoginseng for Cerebral Ischemia: A Systematic Review

source extracted confidence: high 2026-04-09
#amino-acids #animals #anti-inflammatory-agents #antioxidants #apoptosis

Panax notoginseng for Cerebral Ischemia: A Systematic Review

Yang et al., 2020 | Am J Chin Med | Systematic Review

Citation

Yang Fei, Ma Qing, ... Tang Minke. Panax notoginseng for Cerebral Ischemia: A Systematic Review. Am J Chin Med. 2020;48(6):1331-1351. doi:10.1142/S0192415X20500652

Abstract

Panax notoginseng is the most widely used Chinese medicinal herb for the prevention and treatment of ischemic diseases. Its main active ingredients are saponins, including ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1, among others. This review provides an up-to-date overview on the pharmacological roles of P. notoginseng constituents in cerebral ischemia. The saponins of P. notoginseng induce a variety of pharmacological effects in the multiscale mechanisms of cerebral ischemic pathophysiology, including anti-inflammatory activity, reduction of oxidative stress, anti-apoptosis, inhibition of amino acid excitotoxicity, reduction of intracellular calcium overload, protection of mitochondria, repairing the blood-brain barrier, and facilitation of cell regeneration. Regarding cell regeneration, P. notoginseng not only promotes the proliferation and differentiation of neural stem cells, but also protects neurons, endothelial cells and astrocytes in cerebral ischemia. In conclusion, P. notoginseng may treat cerebrovascular diseases through multiple pharmacological effects, and the most critical ones need further investigation.

Key Findings

notoginseng may treat cerebrovascular diseases through multiple pharmacological effects, and the most critical ones need further investigation.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Amino Acids
  • Animals
  • Anti-Inflammatory Agents
  • Antioxidants
  • Apoptosis
  • Blood-Brain Barrier
  • Brain Ischemia
  • Calcium
  • Cell Self Renewal
  • Free Radical Scavengers
  • Ginsenosides
  • Humans
  • Neuroprotective Agents
  • Oxidative Stress
  • Panax notoginseng
  • Phytotherapy
  • Saponins

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: ginseng

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09