Efficacy of curcumin for recurrent aphthous stomatitis: a systematic review

source extracted confidence: high 2026-04-09
#curcumin #humans #pain #stomatitis-aphthous #triamcinolone

Efficacy of curcumin for recurrent aphthous stomatitis: a systematic review

Al-Maweri et al., 2022 | J Dermatolog Treat | Systematic Review

Citation

Al-Maweri Sadeq Ali, Alaizari Nader, ... Almutairi Areej M. Efficacy of curcumin for recurrent aphthous stomatitis: a systematic review. J Dermatolog Treat. 2022-May;33(3):1225-1230. doi:10.1080/09546634.2020.1819529

Abstract

BACKGROUND: Recurrent aphthous stomatitis (RAS) is the most common ulcerative lesion of the oral mucosa. The management of RAS is quite challenging with no definitive cure. OBJECTIVE: The present systematic review aimed to summarize the available evidence regarding the efficacy of curcumin in the management of RAS. METHODS: PubMed, Scopus and Web of Science databases were searched in June 2020 for all relevant studies. Clinical trials that assessed the efficacy of curcumin for the management of RAS were included. The primary outcomes were pain and/or clinical improvement. RESULTS: Eight studies involving 439 subjects were included. The efficacy of curcumin was compared with 1% triamcinolone in four studies, glycerin vehicle in one study, placebo in one study, and honey in one study. Overall, the included studies reported a good efficacy of curcumin in reducing pain and ulcers size in patients with RAS. Four studies found curcumin as effective as triamcinolone in relieving signs and symptoms of RAS. Three studies reported superior results with curcumin as compared with control groups. CONCLUSION: The limited available evidence suggests that curcumin have potential benefits in alleviating pain and accelerating healing in patients with RAS. Further well-designed clinical trials with standardized curcumin formulations are highly recommended.

Key Findings

Eight studies involving 439 subjects were included. The efficacy of curcumin was compared with 1% triamcinolone in four studies, glycerin vehicle in one study, placebo in one study, and honey in one study. Overall, the included studies reported a good efficacy of curcumin in reducing pain and ulcers size in patients with RAS. Four studies found curcumin as effective as triamcinolone in relieving signs and symptoms of RAS. Three studies reported superior results with curcumin as compared with con

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population ras
Sample Size 439
Age Range See abstract
Condition See abstract

MeSH Terms

  • Curcumin
  • Humans
  • Pain
  • Stomatitis, Aphthous
  • Triamcinolone

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09