Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis

source extracted confidence: high 2026-04-09
#adult #athletes #dietary-supplements #female #humans

Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis

Pérez-Gómez et al., 2020 | Nutrients | Meta Analysis

Citation

Pérez-Gómez Jorge, Villafaina Santos, ... Collado-Mateo Daniel. Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis. Nutrients. 2020-Apr-17;12(4). doi:10.3390/nu12041119

Abstract

The purpose of this study was to systematically review the scientific literature about the effects of supplementation with Ashwagandha (Withania somnifera) on maximum oxygen consumption (VO2max), as well as to provide directions for clinical practice. A systematic search was conducted in three electronic databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA). The inclusion criteria were: (a) VO2max data, with means ± standard deviation before and after the supplement intervention, (b) the study was randomized controlled trial (RCT), (c) the article was written in English. The quality of evidence was evaluated according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. A meta-analysis was performed to determine effect sizes. Five studies were selected in the systematic review (162 participants) and four were included in the meta-analysis (142 participants). Results showed a significant enhancement in VO2max in healthy adults and athletes (p = 0.04). The mean difference was 3.00 (95% CI from 0.18 to 5.82) with high heterogeneity. In conclusion, Ashwagandha supplementation might improve the VO2max in athlete and non-athlete people. However, further research is need to confirm this hypothesis since the number of studies is limited and the heterogeneity was high.

Key Findings

However, further research is need to confirm this hypothesis since the number of studies is limited and the heterogeneity was high.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population healthy adults
Sample Size 162
Age Range See abstract
Condition See abstract

MeSH Terms

  • Adult
  • Athletes
  • Dietary Supplements
  • Female
  • Humans
  • Male
  • Oxygen Consumption
  • Physical Fitness
  • Plant Extracts
  • Withania

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: ashwagandha-athletic

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09