The effect of resveratrol on advanced glycation end products in diabetes mellitus: a systematic review

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#animals #antioxidants #diabetes-mellitus #glycation-end-products-advanced #humans

The effect of resveratrol on advanced glycation end products in diabetes mellitus: a systematic review

Maleki et al., 2022 | Arch Physiol Biochem | Systematic Review

Citation

Maleki Vahid, Foroumandi Elaheh, ... Alizadeh Mohammad. The effect of resveratrol on advanced glycation end products in diabetes mellitus: a systematic review. Arch Physiol Biochem. 2022-Feb;128(1):253-260. doi:10.1080/13813455.2019.1673434

Abstract

Advanced glycation end products (AGEs) lead to chronic oxidative stress and inflammation, which in turn augment diabetes complications. Resveratrol plays a potential role in relation to diabetes due to improving of hyperglycemia, oxidative stress, and inflammation. The aim of this review was to evaluate the scientific literature to identify the impacts of resveratrol on the accumulation of AGEs. The literature was searched in the online databases, viz. PubMed, SCOPUS, Embase, ProQuest, and Google Scholar until May 2019. From a total of 338 retrieved articles, 10 papers were eligible for the present analysis. Except one clinical trial, all studies were conducted on animals. All the included studies, except one, showed inhibitory effects of resveratrol on the accumulation of AGE or receptor for AGEs. The findings indicate that resveratrol is a potential protective agent against the accumulation of AGEs. There is, however, the need for future studies to investigate this effect on human.

Key Findings

There is, however, the need for future studies to investigate this effect on human.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition stress

MeSH Terms

  • Animals
  • Antioxidants
  • Diabetes Mellitus
  • Glycation End Products, Advanced
  • Humans
  • Oxidative Stress
  • Resveratrol

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09