Selenium level does not differ in blood but increased in cerebrospinal fluid in Parkinson's disease: a meta-analysis

source extracted confidence: high 2026-04-09
#antioxidants #biomarkers #humans #parkinson-disease #selenium

Selenium level does not differ in blood but increased in cerebrospinal fluid in Parkinson's disease: a meta-analysis

Zhang et al., 2021 | Int J Neurosci | Meta Analysis

Citation

Zhang Yu-Jing, Sun Hua-Lei, ... Li Xing. Selenium level does not differ in blood but increased in cerebrospinal fluid in Parkinson's disease: a meta-analysis. Int J Neurosci. 2021-Jan;131(1):95-101. doi:10.1080/00207454.2020.1733557

Abstract

Objective: Recent studies have found that selenium (Se) levels were associated with the risk of Parkinson's disease (PD), but the results were contradictory. Therefore, this meta-analysis was conducted to investigate the correlation between Se levels and PD.Methods: PubMed, Embase and Web of Science were searched published up to 28 October 2019. The differences between groups were analyzed by forest plots and results were pooled and assessed using a random-effect model. Standardized mean difference (SMD) and 95% confidence interval (CI) were used to assess the association between Se levels and the risk of PD. Subgroup analysis, meta-regression, and sensitivity analysis were also conducted. Publication bias was estimated using Begg's regression asymmetry test.Results: Finally, 12 articles involving 601 PD patients and 749 controls were included in this meta-analysis. The meta-analysis revealed a significantly higher cerebrospinal fluid (CSF) Se level in PD patients than those in controls (SMD = 1.22; 95%CI [0.05, 2.39]; p = 0.000). No publication bias was found.Conclusion: The meta-analysis indicated that CSF Se levels in PD patients were significantly higher than those in controls.

Key Findings

Finally, 12 articles involving 601 PD patients and 749 controls were included in this meta-analysis. The meta-analysis revealed a significantly higher cerebrospinal fluid (CSF) Se level in PD patients than those in controls (SMD = 1.22; 95%CI [0.05, 2.39]; p = 0.000). No publication bias was found.Conclusion: The meta-analysis indicated that CSF Se levels in PD patients were significantly higher than those in controls.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Antioxidants
  • Biomarkers
  • Humans
  • Parkinson Disease
  • Selenium
  • Trace Elements

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09