Melatonin effects on ovarian follicular cells: a systematic review

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#cells-cultured #female #granulosa-cells #humans #melatonin

Melatonin effects on ovarian follicular cells: a systematic review

Minguini et al., 2019 | Rev Assoc Med Bras (1992) | Systematic Review

Citation

Minguini Isabela Pasqualini, Luquetti Camila Maganhin, ... Soares Junior Jose Maria. Melatonin effects on ovarian follicular cells: a systematic review. Rev Assoc Med Bras (1992). 2019-Sep-12;65(8):1122-1127. doi:10.1590/1806-9282.65.8.1122

Abstract

Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone's action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies about melatonin action on the ovarian granulosa/theca interna cells from the literature. METHODS The systematic review was carried out according to the PRISMA recommendations. The MEDLINE and Cochrane primary databases were consulted with the use of specific terms. There was no limitation on language or publication year. RESULTS Seven papers about melatonin action on granulosa cells were selected. The following can be attributed to the hormone's effects: a) progesterone increase in culture medium; b) increased estrogen production; c) antagonistic action on estrogen; d) improvement in cell quality resulting in improved embryo and higher pregnancy rates; e) improved cell proliferation via MAPK; f) reduction of free radicals. Nevertheless, there are contrarian papers reporting a reduction in progesterone production. Melatonin interferes in sex steroid production, boosting progesterone output. Such action may help improve oocyte quality.

Key Findings

Such action may help improve oocyte quality.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition sleep

MeSH Terms

  • Cells, Cultured
  • Female
  • Granulosa Cells
  • Humans
  • Melatonin
  • Oocytes
  • Ovarian Follicle
  • Pregnancy
  • Progesterone
  • Theca Cells

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: melatonin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09