Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#alkaline-phosphatase #antioxidants #biomarkers #bone-density #bone-and-bones

Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta-analysis

Asis et al., 2019 | Ann N Y Acad Sci | Meta Analysis

Citation

Asis Marzieh, Hemmati Niloufar, ... Bishayee Anupam. Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta-analysis. Ann N Y Acad Sci. 2019-Dec;1457(1):92-103. doi:10.1111/nyas.14226

Abstract

The current study presents a comprehensive systematic review and meta-analysis of randomized controlled trials (RCTs) on resveratrol and bone health biomarkers. PubMed, Scopus, and Web of Science (until September 2018) were searched to identify the potential RCTs with information on resveratrol supplementation and bone metabolism biomarkers. Mean differences (MD) were analyzed using a random-effects model. Pooling six RCTs (eight treatment arms with 264 subjects) together identified no significant reduction of serum Ca, osteocalcin, C-terminal telopeptide of type I collagen, and procollagen I N-terminal propeptide values after resveratrol supplementation over placebo treatment. However, a significant increase in serum alkaline phosphatase (ALP) (MD: 5.69 mg/mL, 95% CI: 3.58-7.80, I2  = 95.7%, P < 0.001) and bone alkaline phosphatase (BAP) (MD: 10.57 mmHg, 95% CI: 5.36-15.78, I2  = 99.2%, P < 0.001) values was observed after resveratrol treatment relative to placebo. The findings of this study indicate that resveratrol supplementation increased some key bone biomarkers, such as ALP and BAP. Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.

Key Findings

Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 264
Age Range See abstract
Condition See abstract

MeSH Terms

  • Alkaline Phosphatase
  • Antioxidants
  • Biomarkers
  • Bone Density
  • Bone and Bones
  • Calcium
  • Collagen Type I
  • Enzyme Inhibitors
  • Humans
  • Osteocalcin
  • Parathyroid Hormone
  • Peptide Fragments
  • Peptides
  • Procollagen
  • Randomized Controlled Trials as Topic
  • Resveratrol

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: resveratrol

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09