Does Intradialytic Exercise Improve Removal of Solutes by Hemodialysis? A Systematic Review and Meta-analysis

source extracted confidence: high 2026-04-09
#clinical-studies-as-topic #creatinine #exercise-therapy #humans #phosphates

Does Intradialytic Exercise Improve Removal of Solutes by Hemodialysis? A Systematic Review and Meta-analysis

Ferreira et al., 2019 | Arch Phys Med Rehabil | Meta Analysis

Citation

Ferreira Gustavo D, Bohlke Maristela, ... Orcy Rafael B. Does Intradialytic Exercise Improve Removal of Solutes by Hemodialysis? A Systematic Review and Meta-analysis. Arch Phys Med Rehabil. 2019-Dec;100(12):2371-2380. doi:10.1016/j.apmr.2019.02.009

Abstract

OBJECTIVE: To describe a systematic review and meta-analysis to identify if intradialytic exercise improves the removal of solutes and the hemodialysis adequacy. DATA SOURCES: A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed. The sources were MEDLINE (via PubMed), Web of Science, LILACS, and SciELO, from inception until July 2018. STUDY SELECTION: Clinical trials including patients on chronic hemodialysis submitted to the intervention of aerobic intradialytic exercise. DATA EXTRACTION: Evaluating as outcomes the removal of solutes (creatinine, phosphate, potassium) and/or adequacy parameters (Kt/V-urea). DATA SYNTHESIS: The systematic review included 23 studies (7 evaluating the effect of 1 exercise session and 16 evaluating the effect of training, lasting from 6 to 25 weeks). Eleven RCT were included in the meta-analyses. It was observed that the aerobic intradialytic exercise increased the Kt/V-urea (0.15; 95% confidence interval [95% CI], 0.08-0.21) and decreased creatinine (-1.82 mg/dL; 95% CI, -2.50 to -1.13), despite the high heterogeneity of the analysis. No differences were found in phosphorus and potassium removal. CONCLUSION: The aerobic intradialytic exercise may be suggested to improve the Kt/V-urea and the creatinine removal during the dialysis.

Key Findings

The aerobic intradialytic exercise may be suggested to improve the Kt/V-urea and the creatinine removal during the dialysis.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size 23
Age Range See abstract
Condition See abstract

MeSH Terms

  • Clinical Studies as Topic
  • Creatinine
  • Exercise Therapy
  • Humans
  • Phosphates
  • Potassium
  • Renal Dialysis
  • Renal Insufficiency, Chronic
  • Urea

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: potassium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09