Pharmacological Aspects and Potential Use of Phloretin: A Systemic Review

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#antineoplastic-agents #antioxidants #arthritis-rheumatoid #cardiovascular-diseases #diabetes-mellitus

Pharmacological Aspects and Potential Use of Phloretin: A Systemic Review

Mariadoss et al., 2019 | Mini Rev Med Chem | Systematic Review

Citation

Mariadoss Arokia V A, Vinyagam Ramachandran, ... David Ernest. Pharmacological Aspects and Potential Use of Phloretin: A Systemic Review. Mini Rev Med Chem. 2019;19(13):1060-1067. doi:10.2174/1389557519666190311154425

Abstract

Over the past two decades, many researchers have concluded that a diet rich in polyphenolic compounds plays an important therapeutic role in reducing the risk of cancer, cardiovascular disease, inflammation, diabetes, and other degenerative diseases. Polyphenolic compounds have been reported to be involved in neutralization of reactive oxygen species and charged radicals, and have anticarcinogenic effects, hepatoprotective effects, low-glycaemic response, and other benefits. The benefits of fruits and vegetables may be partly attributable to polyphenolic compounds, which have antioxidant and free radical scavenging properties. Fruits such as apples contain a variety of phytochemicals, including (+)-catechin and (-)-epicatechin, phlorizin, phloretin quercetin, cyanidin-3-Ogalactoside, chlorogenic acid, and p-coumaric acid, all of which are strong antioxidants. Phloretin, a natural phenolic compound, is a dihydrochalcone, which is present in the apple. It exhibits a wide variety of activities such as antioxidative, anti-inflammatory, anti-microbial, anti-allergic, anticarcinogenic, anti-thrombotic, and hepatoprotective, besides being involved in the activation of apoptotic associated gene expression and signal transduction in molecular pathways. Despite a multitude of clinical studies, new efforts are needed in clinical research to determine the complete therapeutic potential of phloretin.

Key Findings

Despite a multitude of clinical studies, new efforts are needed in clinical research to determine the complete therapeutic potential of phloretin.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition diabetes

MeSH Terms

  • Antineoplastic Agents
  • Antioxidants
  • Arthritis, Rheumatoid
  • Cardiovascular Diseases
  • Diabetes Mellitus
  • Humans
  • Hypoglycemic Agents
  • Inflammation
  • Neoplasms
  • Phloretin

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: quercetin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09