Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis

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#adolescent #adult #aged #antihypertensive-agents #arterial-pressure

Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis

Emami et al., 2019 | J Hum Hypertens | Meta Analysis

Citation

Emami Mohammad Reza, Safabakhsh Maryam, ... Khosroshahi Mohammad Zeinali. Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis. J Hum Hypertens. 2019-Jul;33(7):499-507. doi:10.1038/s41371-019-0192-0

Abstract

Although emerging evidence suggests that vitamin E may contribute to blood pressure improvement, the effects of vitamin E on systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) are still controversial. The aim was to evaluate the influence of vitamin E on SBP, DBP, and MAP through meta-analysis. We identified all studies that assessed the effect of vitamin E supplementation on SBP, DBP, and MAP from PubMed/Medline, SCOPUS, and Google scholar up to March 2018. Weighted mean differences (WMD) and 95% confidence interval (CI) were expressed as effect size. Pre-specified subgroup analysis was conducted to evaluate potential sources of heterogeneity. Meta-regression analyses were performed to investigate association between blood pressure-lowering effects of vitamin E and duration of follow-up and dose of treatment. Eighteen trials, comprising 839 participants met the eligibility criteria. Results of this study showed that compared to placebo, SBP decreased significantly in vitamin E group (WMD = -3.4 mmHg, 95% CI = -6.7 to -0.11, P < 0.001), with a high heterogeneity across the studies (I2 = 94.0%, P < 0.001). Overall, there were no significant effects on DBP and MAP. This meta-analysis suggested that vitamin E supplements decreased only SBP and had no favorable effect on DBP and MAP.

Key Findings

This meta-analysis suggested that vitamin E supplements decreased only SBP and had no favorable effect on DBP and MAP.

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • diastolic blood pressure

Population

Field Value
Population See abstract
Sample Size 839
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Adolescent
  • Adult
  • Aged
  • Antihypertensive Agents
  • Arterial Pressure
  • Dietary Supplements
  • Female
  • Humans
  • Hypertension
  • Male
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Vitamin E
  • Young Adult

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-e

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09