Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies

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#animals #blood-glucose #dose-response-relationship-drug #hypoglycemic-agents #quercetin

Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies

Bule et al., 2019 | Food Chem Toxicol | Meta Analysis

Citation

Bule Mohammed, Abdurahman Ahmed, ... Amini Mohsen. Antidiabetic effect of quercetin: A systematic review and meta-analysis of animal studies. Food Chem Toxicol. 2019-Mar;125:494-502. doi:10.1016/j.fct.2019.01.037

Abstract

Quercetin is a plant polyphenol with biological activities such as anti-inflammatory, anticancer, antidiabetic, neuroprotective and anti-allergic. The objective of this review is to provide a systematic evaluation of the evidence and a meta-analysis of data from previously published researches on the antidiabetic action of quercetin. A comprehensive literature search was conducted between July 2018 and August 2018 on PubMed, EMBASE, Web of Sciences and Scopus databases. A random-effects model was used to estimate the pooled effect size and studies were weighted according to an estimate of the mean difference. The heterogeneity between studies was assessed using a Higgins' I2 test with corresponding p values. Overall 13 eligible articles with appropriate data on serum glucose were included in the statistical analysis. The meta-analysis for serum glucose level (mg/dL) showed that at doses of 10, 25 and 50 mg/kg there was a significant difference between the means. Therefore, the results of the meta-analysis support the hypothesis that quercetin lowers serum glucose level, at doses of 10, 25 and 50 mg/kg.

Key Findings

Therefore, the results of the meta-analysis support the hypothesis that quercetin lowers serum glucose level, at doses of 10, 25 and 50 mg/kg.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Blood Glucose
  • Dose-Response Relationship, Drug
  • Hypoglycemic Agents
  • Quercetin

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: quercetin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09