Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis

source extracted confidence: high 2026-04-09
#copper #humans #psoriasis #selenium #trace-elements

Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis

Chen et al., 2019 | Biol Trace Elem Res | Meta Analysis

Citation

Chen Wangqing, Zhou Xingchen, Zhu Wu. Trace Elements Homeostatic Imbalance in Psoriasis: a Meta-Analysis. Biol Trace Elem Res. 2019-Oct;191(2):313-322. doi:10.1007/s12011-018-1626-1

Abstract

Studies point out that trace elements take vital roles in immunological and inflammatory reactions, such as psoriasis, while the conclusions are controversial. The purpose of this study was to analyze the existing literatures and explore the relationship between the risk of psoriasis and four trace elements zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). We identified 42 studies through the databases PubMed, Embase, Cochrane Library, Google Scholar, and Web of knowledge. After the meta-analysis, the serum zinc, iron, and selenium levels showed no remarkable difference between psoriasis and controls. The people with psoriasis showed a higher level of zinc in lesion tissue (standard mean difference (SMD) = 14.43; 95% confidence interval (CI), 7.89-20.97; P < 0.0001), and a higher level of serum copper than controls (SMD = 18.23; 95% CI, 5.06-31.40; P = 0.007). Our findings indicated that the trace element of copper and zinc levels are in a homeostatic imbalance in psoriasis patients when compared with controls, which raise the question whether this imbalance can be taken as the therapy target for psoriasis.

Key Findings

Our findings indicated that the trace element of copper and zinc levels are in a homeostatic imbalance in psoriasis patients when compared with controls, which raise the question whether this imbalance can be taken as the therapy target for psoriasis.

Outcomes Measured

  • inflammatory markers

Population

Field Value
Population See abstract
Sample Size 42
Age Range See abstract
Condition See abstract

MeSH Terms

  • Copper
  • Humans
  • Psoriasis
  • Selenium
  • Trace Elements
  • Zinc

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09