Polymorphism of reduced folate carrier 1 (A80G) and non-syndromic cleft lip/palate: A systematic review and meta-analysis

source extracted confidence: high 2026-04-09
#alleles #cleft-lip #databases-factual #gene-frequency #genetic-predisposition-to-disease

Polymorphism of reduced folate carrier 1 (A80G) and non-syndromic cleft lip/palate: A systematic review and meta-analysis

Imani et al., 2019 | Arch Oral Biol | Meta Analysis

Citation

Imani Mohammad Moslem, Mozaffari Hamid Reza, ... Sadeghi Masoud. Polymorphism of reduced folate carrier 1 (A80G) and non-syndromic cleft lip/palate: A systematic review and meta-analysis. Arch Oral Biol. 2019-Feb;98:273-279. doi:10.1016/j.archoralbio.2018.12.005

Abstract

OBJECTIVE: To evaluate the association between polymorphism of reduced folate carrier 1 (RFC1) A80 G in infants and the risk of non-syndromic cleft lip/palate (NSCL/P), in a meta-analysis of case-control studies. DESIGN: We searched databases of PubMed, Scopus, Web of Science, and Cochrane Library for studies on the association of mentioned polymorphism and NSCL/P risk published until August 2018. RESULTS: Seven articles were selected based on the criteria and were analyzed in this meta-analysis (1486 NSCL/P patients and 1596 controls). Overall, it was not obtained a significant association between the polymorphism and NSCL/P risk, with the exception of the recessive model (odds ratio = 1.45; 95% confidence interval = 1.03, 2.05; P = 0.03). A subgroup analysis showed that the frequency of GG genotype in the homozygote and recessive models in the Caucasian ethnicity was significantly higher in NSCL/P patients than in controls. Sensitivity analysis showed that the frequency of G allele and GG genotype in NSCL/P cases was significantly higher than that in controls. CONCLUSIONS: The results identified an association between the GG genotype and NSCL/P risk and just confirmed this association in the Caucasian ethnicity. Therefore, the GG genotype of RFC1 (A80 G) polymorphism can be related to NSCL/P risk in some ethnicities more than others.

Key Findings

Seven articles were selected based on the criteria and were analyzed in this meta-analysis (1486 NSCL/P patients and 1596 controls). Overall, it was not obtained a significant association between the polymorphism and NSCL/P risk, with the exception of the recessive model (odds ratio = 1.45; 95% confidence interval = 1.03, 2.05; P = 0.03). A subgroup analysis showed that the frequency of GG genotype in the homozygote and recessive models in the Caucasian ethnicity was significantly higher in NSCL

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Alleles
  • Cleft Lip
  • Databases, Factual
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Genotype
  • Humans
  • Infant
  • Palate
  • Polymorphism, Genetic
  • Reduced Folate Carrier Protein

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: folate

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09