In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature

Shi et al., 2019 | Biomed Pharmacother | Systematic Review

Citation

Shi Guang-Jiang, Li Yan, ... Yang Yong. In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature. Biomed Pharmacother. 2019-Jan;109:1085-1099. doi:10.1016/j.biopha.2018.10.130

Abstract

Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes and its complications with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a promising molecule for the treatment of these diseases. Finally, we contemplate future development and application prospects of quercetin. Despite the wealth of in animal research results suggesting the anti-diabetic and its complications potential of quercetin, its efficacy in diabetic human subjects is yet to be explored. The problem may become an important direction in the future research.

Key Findings

The problem may become an important direction in the future research.

Outcomes Measured

inflammatory markers

Population

Field	Value
Population	See abstract
Sample Size	See abstract
Age Range	See abstract
Condition	diabetes

MeSH Terms

Animals
Antioxidants
Diabetes Complications
Diabetes Mellitus
Flavonoids
Humans
Protective Agents
Quercetin

Evidence Classification

Level: Systematic Review
Publication Types: Journal Article, Systematic Review
Vertical: quercetin

Provenance

PMID: 30551359
DOI: 10.1016/j.biopha.2018.10.130
PMCID: Not in PMC
Verified: 2026-04-09 via PubMed E-utilities API

Source extracted via PubMed E-utilities API on 2026-04-09