Ascorbic Acid Supplements and Kidney Stones Incidence Among Men and Women: A systematic review and meta-analysis

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Ascorbic Acid Supplements and Kidney Stones Incidence Among Men and Women: A systematic review and meta-analysis

Jiang et al., 2019 | Urol J | Meta Analysis

Citation

Jiang Kehua, Tang Kun, ... Chen Zhiqiang. Ascorbic Acid Supplements and Kidney Stones Incidence Among Men and Women: A systematic review and meta-analysis. Urol J. 2019-May-05;16(2):115-120. doi:10.22037/uj.v0i0.4275

Abstract

PURPOSE: The relationship of ascorbic acid (AA) supplements and risk of kidney stones among men and women is controversial. This systematic evaluation was performed to obtain comprehensive evidence about the relationship of AA supplements and risk of kidney stones among men and women. MATERIAL AND METHODS: A systematic search of Pubmed, the Cochrane Library, Web of Science, Embase was performed to identify studies that exhibited the relationship of AA supplements and risk of kidney stones among men and women were published up to Mar 2017. Outcomes of interest included kidney stones incidence and risk factors. RESULTS: Four studies estimating the association between AA supplements and risk of kidney stones were included for meta-analysis. The kidney stones incidence was significantly higher in men than women with AA supplements (OR= 1.62; 95% CI: 1.09 to 2.42; P=0.02). AA supplements (250-499mg/d, 1000-1499mg/d) was remarkably correlated with the risk of renal stones among men (OR= 1.14, 95% CI: 1.00 to 1.28, P=0.04; OR= 1.12, 95% CI: 1.11 to 1.13, P<0.00001; respectively). However, AA supplements (500-999 mg/d, >1500 mg/d) did not correlate with the risk of renal stones among men (OR= 1.20, 95% CI: 0.99 to 1.46, P=0.06; OR= 1.28, 95% CI: 1.00 to 1.63, P= 0.05; respectively). In addition, AA supplements (250-499mg/d, 500-999mg/d, 1000-1499mg/d, >1500mg/d) did not remarkably correlate with the risk of renal stones among women (OR= 1.00, 95% CI: 0.82 to 1.22, P=0.98; OR= 1.08, 95% CI: 0.99 to 1.18, P=0.09; OR= 0.99, 95% CI: 0.90 to 1.08, P=0.77; OR= 0.99, 95% CI: 0.99 to 1.09, P=0.88; respectively). CONCLUSIONS: AA supplements was remarkably correlated with higher risk for kidney stones incidence in men, but not in women. Further multicenter, prospective and long-term follow-up RCTs are required to verify these findings.

Key Findings

Four studies estimating the association between AA supplements and risk of kidney stones were included for meta-analysis. The kidney stones incidence was significantly higher in men than women with AA supplements (OR= 1.62; 95% CI: 1.09 to 2.42; P=0.02). AA supplements (250-499mg/d, 1000-1499mg/d) was remarkably correlated with the risk of renal stones among men (OR= 1.14, 95% CI: 1.00 to 1.28, P=0.04; OR= 1.12, 95% CI: 1.11 to 1.13, P<0.00001; respectively). However, AA supplements (500-999 mg/

Outcomes Measured

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Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition See abstract

MeSH Terms

  • Ascorbic Acid
  • Dietary Supplements
  • Female
  • Humans
  • Incidence
  • Kidney Calculi
  • Male
  • Risk Assessment
  • Sex Distribution
  • Vitamins

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Systematic Review
  • Vertical: vitamin-c

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09