Systematic review and meta-analysis of interventions tested in animal models of pulmonary hypertension

source extracted confidence: high 2026-04-09
#animals #antihypertensive-agents #arterial-pressure #disease-models-animal #hypertension-pulmonary

Systematic review and meta-analysis of interventions tested in animal models of pulmonary hypertension

Sztuka et al., 2018 | Vascul Pharmacol | Meta Analysis

Citation

Sztuka Katarzyna, Orszulak-Michalak Daria, Jasińska-Stroschein Magdalena. Systematic review and meta-analysis of interventions tested in animal models of pulmonary hypertension. Vascul Pharmacol. 2018-Nov;110:55-63. doi:10.1016/j.vph.2018.08.004

Abstract

A systematic review and meta-analysis was performed to test candidate therapeutic approaches in pulmonary hypertension (PH). The efficacy of 522 interventions with >200 unregistered drugs was tested on 7254 animals. We propose a modified formula to assess meta-data that concerns the contribution of PH animal model to the denoted efficacy of tested agents. The measure of efficacy expressed as a response ratio for right ventricle systolic pressure was 0.48 (95% CI, 0.46-0.50; P < 0.00001), mean pulmonary artery pressure was 0.54 (0.52-0.56; P < 0.00001), right ventricle hypertrophy was 0.49 (0.48-0.51; P < 0.00001) and pulmonary artery wall thickness was 0.58 (0.56-0.61; P < 0.00001). Only 41 out of 522 interventions were ineffective. The most potent agents to improve both haemodynamic and hypertrophic parameters were ATP-sensitive potassium channel openers with iptakalim, Rho/ROCK inhibitors with fasudil, RAAS regulators with adenosine and ACE2 activators, and anti-inflammatories with n-3 polyunsaturated fatty acids and NF-кB inhibitors.

Key Findings

The most potent agents to improve both haemodynamic and hypertrophic parameters were ATP-sensitive potassium channel openers with iptakalim, Rho/ROCK inhibitors with fasudil, RAAS regulators with adenosine and ACE2 activators, and anti-inflammatories with n-3 polyunsaturated fatty acids and NF-кB inhibitors.

Outcomes Measured

  • systolic blood pressure

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition hypertension

MeSH Terms

  • Animals
  • Antihypertensive Agents
  • Arterial Pressure
  • Disease Models, Animal
  • Hypertension, Pulmonary
  • Hypertrophy, Right Ventricular
  • Molecular Targeted Therapy
  • Pulmonary Artery
  • Signal Transduction
  • Vascular Remodeling
  • Ventricular Function, Right
  • Ventricular Remodeling

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: potassium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09