The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis

source extracted confidence: high 2026-04-09
#animals #cardiomyopathy-dilated #case-control-studies #heart-failure #humans

The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis

Yu et al., 2018 | Biomed Res Int | Meta Analysis

Citation

Yu Xuefang, Huang Lei, ... Bian Bo. The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis. Biomed Res Int. 2018;2018:2739014. doi:10.1155/2018/2739014

Abstract

Zinc is essential for the maintenance of normal cellular structure and functions. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. However, there are conflicting reports on the relationship between serum zinc levels and heart failure (HF). The purpose of the present study is to explore the relationship between serum zinc levels and HF by using a meta-analysis approach. PubMed, Web of Science, and OVID databases were searched for reports on the association between serum zinc levels and HF until June 2016. 12 reports with 1453 subjects from 27 case-control studies were chosen for the meta-analysis. Overall, the pooled analysis indicated that patients with HF had lower zinc levels than the control subjects. Further subgroup analysis stratified by different geographic locations also showed that HF patients had lower zinc levels than the control subjects. In addition, subgroup analysis stratified by HF subgroups found that patients with idiopathic dilated cardiomyopathy (IDCM) had lower zinc levels than the control subjects, except for patients with ischemic cardiomyopathy (ICM). In conclusion, the results of the meta-analysis indicate that there is a significant association between low serum zinc levels and HF.

Key Findings

In conclusion, the results of the meta-analysis indicate that there is a significant association between low serum zinc levels and HF.

Outcomes Measured

  • Requires manual extraction

Population

Field Value
Population hf had lower zinc
Sample Size 1453
Age Range See abstract
Condition See abstract

MeSH Terms

  • Animals
  • Cardiomyopathy, Dilated
  • Case-Control Studies
  • Heart Failure
  • Humans
  • Risk Factors
  • Zinc

Evidence Classification

  • Level: Meta Analysis
  • Publication Types: Journal Article, Meta-Analysis, Review
  • Vertical: zinc

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09