Dietary intervention and health in patients with systemic lupus erythematosus: A systematic review of the evidence

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#diet #humans #lupus-erythematosus-systemic #nutritional-support

Dietary intervention and health in patients with systemic lupus erythematosus: A systematic review of the evidence

de et al., 2019 | Crit Rev Food Sci Nutr | Systematic Review

Citation

de Medeiros Marília Cristina Santos, Medeiros Jussara Cristina Alves, ... Knackfuss Maria Irany. Dietary intervention and health in patients with systemic lupus erythematosus: A systematic review of the evidence. Crit Rev Food Sci Nutr. 2019;59(16):2666-2673. doi:10.1080/10408398.2018.1463966

Abstract

Objective: The aim of this study was to evaluate the scientific evidence of dietary intervention, either through diet or supplementation, and its effects on the health of patients with systemic lupus erythematosus. Methods: Literature searches were conducted using Scopus, PubMed, BioMed Central and Science Direct databases. The terms used for the search were diet, nutritional support, nutrition therapy and systemic lupus erythematosus. Results: Eleven studies with interventions related to supplementation of omega-3 fatty acids, vitamin D and turmeric, as well as changes in diet composition, such as low glycaemic index diet were identified. Conclusions: The studies evidenced that omega-3 supplementation reduced inflammation, disease activity, endothelial dysfunction and oxidative stress; vitamin D supplementation increased serum levels, reduced inflammatory and hemostatic markers; turmeric supplementation reduced proteinuria, hematuria and systolic blood pressure; and low glycaemic index diet caused weight loss and reduced fatigue.

Key Findings

Eleven studies with interventions related to supplementation of omega-3 fatty acids, vitamin D and turmeric, as well as changes in diet composition, such as low glycaemic index diet were identified. Conclusions: The studies evidenced that omega-3 supplementation reduced inflammation, disease activity, endothelial dysfunction and oxidative stress; vitamin D supplementation increased serum levels, reduced inflammatory and hemostatic markers; turmeric supplementation reduced proteinuria, hematuria

Outcomes Measured

  • blood pressure
  • systolic blood pressure
  • inflammatory markers

Population

Field Value
Population systemic lupus erythematosus
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Diet
  • Humans
  • Lupus Erythematosus, Systemic
  • Nutritional Support

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Systematic Review
  • Vertical: curcumin

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09