Selenium intake and metabolic syndrome: A systematic review

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#adult #aged #humans #metabolic-syndrome #middle-aged

Selenium intake and metabolic syndrome: A systematic review

Retondario et al., 2019 | Clin Nutr | Systematic Review

Citation

Retondario Anabelle, Fernandes Ricardo, ... Vasconcelos Francisco de Assis Guedes de. Selenium intake and metabolic syndrome: A systematic review. Clin Nutr. 2019-Apr;38(2):603-614. doi:10.1016/j.clnu.2018.02.021

Abstract

BACKGROUND & AIMS: Metabolic syndrome is a multi-causal disease. Its treatment includes lifestyle changes with a focus on weight loss. This systematic review assessed the association between Selenium intake and metabolic syndrome. METHODS: Data were collected mainly from four databases: PubMed, CENTRAL (Cochrane), Scopus and Web of Knowledge. Keywords related to metabolic syndrome, selenium, as well as metabolic syndrome features were searched. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. A systematic review protocol was registered at PROSPERO (n. 42016046321). Two reviewers independently screened 2957 abstracts. Six studies were included to perform data extraction with standardized spreadsheets. The risk of bias was assessed by using specific tools according to the design of the relevant studies. An assessment was carried out based on the appropriateness of the study reports accordingly to STROBE and the CONSORT-based checklist for each study design. RESULTS: Three studies found no association between Selenium intake and metabolic syndrome; two of them found an inverse association; and one study found a direct association between Selenium intake and metabolic syndrome. One study also showed an inverse association between Selenium intake and the prevalence of high waist circumference, high diastolic blood pressure, and hyperglycaemia in women. CONCLUSIONS: Overall, based on the argumentation and results of this study, it is possible to conclude that Selenium intake and metabolic syndrome are not clearly associated in adults and elderly.

Key Findings

Three studies found no association between Selenium intake and metabolic syndrome; two of them found an inverse association; and one study found a direct association between Selenium intake and metabolic syndrome. One study also showed an inverse association between Selenium intake and the prevalence of high waist circumference, high diastolic blood pressure, and hyperglycaemia in women.

Outcomes Measured

  • blood pressure
  • diastolic blood pressure

Population

Field Value
Population See abstract
Sample Size See abstract
Age Range See abstract
Condition blood pressure

MeSH Terms

  • Adult
  • Aged
  • Humans
  • Metabolic Syndrome
  • Middle Aged
  • Selenium

Evidence Classification

  • Level: Systematic Review
  • Publication Types: Journal Article, Research Support, Non-U.S. Gov't, Systematic Review
  • Vertical: selenium

Provenance

Source extracted via PubMed E-utilities API on 2026-04-09